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Study Information
Study Attribute Value
CEBS Accession Number: 002-01632-0002-0000-6
Chemical Name: Allyl glycidyl ether
CASRN: 106-92-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 691488_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 03/12/1984    Harvest Time: 21.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Allyl glycidyl ether 
60         
 100 7 0.070 6.0 1 0.010 1.0 6 0.060 5.0 0 0.000 0.0 
64.8       
 100 13 0.130 11.0 8 0.080 7.0 5 0.050 5.0 0 0.000 0.0 
70.7       
 100 20 0.200 14.0 10 0.100 9.0 10 0.100 8.0 0 0.000 0.0 
79.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.025     
 100 12 0.120 11.0 7 0.070 7.0 5 0.050 5.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 17 0.680 36.0 8 0.320 28.0 9 0.360 20.0 0 0.000 0.0
Trend: 3.326 3.192 2.233  
Probability: 0.000 0.001 0.013  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/12/1984    Harvest Time: 21.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Allyl glycidyl ether 
130.2       
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
150         
 100 17 0.170 13.0 10 0.100 9.0 7 0.070 6.0 0 0.000 0.0 
176         
 25 62 2.480 68.0 21 0.840 40.0 20 0.800 40.0 21 0.840 12.0 
200         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 8 0.320 28.0 3 0.120 8.0 5 0.200 20.0 0 0.000 0.0
Trend: 7.007 5.849 4.938  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 03/20/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 50 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 50 3 0.060 4.0 0 0.000 0.0 3 0.060 4.0 0 0.000 0.0
Test Chemical: Allyl glycidyl ether 
74.7       
 50 25 0.500 30.0 12 0.240 22.0 13 0.260 16.0 0 0.000 0.0 
80         
 50 9 0.180 12.0 5 0.100 8.0 4 0.080 8.0 0 0.000 0.0 
90         
 50 28 0.560 30.0 14 0.280 22.0 14 0.280 22.0 0 0.000 0.0 
100.1       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.025     
 50 5 0.100 8.0 3 0.060 6.0 2 0.040 4.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 8 0.320 28.0 1 0.040 4.0 7 0.280 28.0 0 0.000 0.0
Trend: 2.644 2.647 2.369  
Probability: 0.004 0.004 0.009