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Study Information
Study Attribute Value
CEBS Accession Number: 002-01633-0001-0000-6
Chemical Name: Allyl isothiocyanate
CASRN: 57-06-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 630852_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Questionable 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 05/05/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 518 0.494 10.36 26.0 0.000
Test Chemical Allyl isothiocyanate 
 0.16      
 50 1041 487 0.468 9.74 26.0 -5.262 
 0.5       
 50 1048 556 0.531 11.12 26.0 7.438
Positive Control Mitomycin-C 
 0.005     
 50 1050 1174 1.118 23.48 26.0 126.425
Trend: 1.192        
Probability: 0.117        

Trial #: 2    Activation: No Activation    Date: 09/16/1982    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 474 0.452 9.48 26.0 0.000
Test Chemical Allyl isothiocyanate 
 0.1       
 50 1046 455 0.435 9.10 26.0 -3.733 
 0.2       
 50 1044 545 0.522 10.90 26.0 15.530 
 0.3       
 50 1047 516 0.493 10.32 26.0 9.069 
 0.4       
 50 1044 518 0.496 10.36 26.0 9.806 
 0.5       
 50 1044 536 0.513 10.72 26.0 13.622
Positive Control Mitomycin-C 
 0.005     
 25 525 616 1.173 24.64 26.0 159.668
Trend: 2.820        
Probability: 0.002        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/05/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 461 0.439 9.22 26.0 0.000
Test Chemical Allyl isothiocyanate 
 0.16      
 50 1047 571 0.545 11.42 26.0 24.334 
 0.5       
 50 1050 541 0.515 10.82 26.0 17.465 
1.6       
 50 1027 680 0.662 13.60 28.0 50.952
Positive Control Cyclophosphamide 
1         
 50 1049 862 0.822 17.24 26.0 87.341
Trend: 6.281        
Probability: 0.000