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Study Information
Study Attribute Value
CEBS Accession Number: 002-01633-0002-0000-7
Chemical Name: Allyl isothiocyanate
CASRN: 57-06-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 630852_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Weakly Positive* 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 05/05/1982    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Allyl isothiocyanate
 0.5       
100 8 0.080 8.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0
1.6       
100 14 0.140 13.0 3 0.030 3.0 11 0.110 10.0 0 0.000 0.0
5         
100 49 0.490 36.0 2 0.020 2.0 47 0.470 34.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.15      
100 37 0.370 30.0 12 0.120 12.0 25 0.250 21.0 0 0.000 0.0
Trend: 6.046 0.642 6.140  
Probability: 0.000 0.261 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/05/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 10 0.100 7.0 1 0.010 1.0 9 0.090 6.0 0 0.000 0.0
Test Chemical: Allyl isothiocyanate
 0.5       
100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0
1.6       
100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0
5         
100 11 0.110 9.0 1 0.010 1.0 10 0.100 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide
15         
100 21 0.210 20.0 10 0.100 10.0 11 0.110 10.0 0 0.000 0.0
Trend: 0.442 -0.003 0.459  
Probability: 0.329 0.501 0.323  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/22/1982    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Allyl isothiocyanate
3         
100 7 0.070 7.0 0 0.000 0.0 7 0.070 7.0 0 0.000 0.0
4         
100 11 0.110 10.0 0 0.000 0.0 11 0.110 10.0 0 0.000 0.0
5         
100 16 0.160 15.0 5 0.050 5.0 11 0.110 10.0 0 0.000 0.0
Positive Control: Cyclophosphamide
15         
100 18 0.180 14.0 8 0.080 8.0 10 0.100 8.0 0 0.000 0.0
Trend: 2.794 2.915 1.779  
Probability: 0.003 0.002 0.038