Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01633-0014-0000-0 |
Chemical Name: | Allyl isothiocyanate |
CASRN: | 57-06-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 352025 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 82 | 114 | 66 | 27 | 43 |
71 | 109 | 70 | 33 | ||||
58 | 77 | 120 | 70 | ||||
45r | 46 | 123 | 92 | ||||
Test Chemical | Allyl isothiocyanate | 0.05 | 72 | 87 | 79 | 36 | 55 |
35 | 47 | 77 | 73 | ||||
0.1 | 80 | 81 | 127 | 53 | 61 | ||
29 | 37 | 60 | 69 | ||||
0.2 | 77 | 60 | 100 | 43 | 39 | ||
57 | 58 | 59 | 35 | ||||
0.4 | 46 | 22 | 58 | 42 | 70 | ||
31 | 12 | 90 | 97 | ||||
0.8 | 24# | 5 | 71 | 98 | 69 | ||
31# | 7 | 38 | 41 | ||||
Positive Control | Other Positive Control | 15 | 6r | 4 | 136 | 735 | 163* |
30 | 17 | 145 | 163 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 92 | 93 | 145 | 52 | 60 |
110 | 127 | 168 | 51 | ||||
81 | 90 | 178 | 74 | ||||
75 | 90 | 142 | 63 | ||||
Test Chemical | Allyl isothiocyanate | 0.2 | 68 | 58 | 165 | 81 | 74 |
87 | 61 | 174 | 67 | ||||
0.4 | 64 | 15 | 236 | 122 | 109* | ||
53 | 14 | 152 | 96 | ||||
0.6 | 40 | 6 | 189 | 159 | 145* | ||
39 | 6 | 151 | 131 | ||||
0.8 | 26 | 3 | 179 | 228 | 247* | ||
18 | 2 | 144 | 267 | ||||
1 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 46 | 34 | 257 | 188 | 198* |
47 | 31 | 291 | 208 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 99 | 102 | 104 | 35 | 40 |
92 | 102 | 107 | 39 | ||||
82 | 110 | 111 | 45 | ||||
77 | 87 | 98 | 42 | ||||
Test Chemical | Allyl isothiocyanate | 0.6 | 47 | 11 | 89 | 64 | 68* |
46 | 11 | 102 | 73 | ||||
0.8 | 42 | 5 | 73 | 59 | 69* | ||
38 | 7 | 90 | 79 | ||||
1 | 41 | 4 | 85 | 70 | 87* | ||
40 | 4 | 123 | 103 | ||||
1.2 | 34 | 4 | 99 | 97 | 94* | ||
32 | 3 | 87 | 90 | ||||
1.4 | 20 | 2 | 136 | 227 | 196* | ||
23 | 2 | 113 | 165 | ||||
1.6 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 42 | 43 | 184 | 145 | 124* |
49 | 41 | 151 | 103 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination