Genetic Toxicology - Rodent Cytogenetics

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01633-0015-0000-1
Chemical Name:	Allyl isothiocyanate
CASRN:	57-06-7
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	056227_SCE
Study Result:	Positive

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Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.

Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	08/02/88	42	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 42 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Dimethyl Sulfoxide	0	4	4.59 ± 0.405
Test Chemical	Allyl isothiocyanate	12.5	4	5.08 ± 0.605
		25	4	5.39 ± 0.504
		50	4	7.39 ± 0.990
Positive Control	Dimethylbenzanthracene	2.5	4	13.99 ± 0.802

Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	09/01/88	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Dimethyl Sulfoxide	0	4	4.56 ± 0.230
Test Chemical	Allyl isothiocyanate	12.5	4	5.29 ± 0.347
		25	4	5.63 ± 0.246
		50	4	6.18 ± 0.718
Positive Control	Dimethylbenzanthracene	2.5	4	12.79 ± 0.720

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed