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Study Information
Study Attribute Value
CEBS Accession Number: 002-01633-0016-0000-2
Chemical Name: Allyl isothiocyanate
CASRN: 57-06-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 056227_CA
Study Result: Equivocal

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/15/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0704
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 9.25 ± 1.56 0.0000
Test Chemical Allyl isothiocyanate 
12.5       
 8 0.00 ± 0.00 0.8415
  
25         
 8 0.75 ± 0.37 0.1580
  
50         
 8 0.75 ± 0.53 0.1580
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/29/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0166
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 19.00 ± 1.73 0.0000
Test Chemical Allyl isothiocyanate 
12.5       
 8 0.75 ± 0.37 0.5000
  
25         
 8 1.25 ± 0.53 0.2386
  
50         
 8 2.25 ± 0.59 0.0405
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.75 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/14/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0151
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 18.75 ± 2.48 0.0000
Test Chemical Allyl isothiocyanate 
25         
 8 1.50 ± 0.98 0.3807
  
37.5       
 8 2.25 ± 0.45 0.1404
  
50         
 8 3.50 ± 1.35 0.0183
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed