Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01634-0001-0000-7 |
Chemical Name: | Allyl isovalerate |
CASRN: | 2835-39-4 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 286848_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
Induced Rat Liver S9 | 2_S9 | Weakly Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1046 | 449 | 0.429 | 8.98 | 26.0 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1044 | 424 | 0.406 | 8.48 | 26.0 | -5.387 | |
Test Chemical | Allyl isovalerate | 16 | 50 | 1045 | 443 | 0.424 | 8.86 | 26.0 | -1.242 |
50 | 50 | 1041 | 457 | 0.439 | 9.14 | 26.0 | 2.271 | ||
160 | 50 | 1047 | 482 | 0.460 | 9.64 | 26.0 | 7.247 | ||
500 | 50 | 1040 | 640 | 0.615 | 12.80 | 26.0 | 43.361 | ||
Positive Control | Mitomycin-C | 0.005 | 50 | 1044 | 1472 | 1.410 | 29.44 | 26.0 | 228.468 |
Trend: | 6.055 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1024 | 395 | 0.386 | 7.90 | 26.0 | -11.855 |
Dimethyl Sulfoxide | 0 | 50 | 1042 | 456 | 0.438 | 9.12 | 26.0 | 0.000 | |
Test Chemical | Allyl isovalerate | 100 | 50 | 1039 | 465 | 0.448 | 9.30 | 26.0 | 2.268 |
250 | 50 | 1030 | 502 | 0.487 | 10.04 | 31.0 | 11.370 | ||
500 | 50 | 1043 | 619 | 0.593 | 12.38 | 31.0 | 35.615 | ||
750 | 50 | 1047 | 695 | 0.664 | 13.90 | 36.0 | 51.684 | ||
Positive Control | Mitomycin-C | 0.003 | 50 | 1036 | 1537 | 1.484 | 30.74 | 26.0 | 239.013 |
Trend: | 8.220 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1037 | 451 | 0.435 | 9.02 | 26.0 | 6.573 |
Dimethyl Sulfoxide | 0 | 50 | 1039 | 424 | 0.408 | 8.48 | 26.0 | 0.000 | |
Test Chemical | Allyl isovalerate | 5 | 50 | 1039 | 385 | 0.371 | 7.70 | 26.0 | -9.198 |
16 | 50 | 1038 | 435 | 0.419 | 8.70 | 26.0 | 2.693 | ||
50 | 50 | 1026 | 446 | 0.435 | 8.92 | 26.0 | 6.521 | ||
160 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 1.5 | 50 | 1043 | 1947 | 1.867 | 38.94 | 26.0 | 357.437 |
Trend: | 1.441 | ||||||||
Probability: | 0.075 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1045 | 422 | 0.404 | 8.44 | 26.0 | -8.673 |
Dimethyl Sulfoxide | 0 | 50 | 1029 | 455 | 0.442 | 9.10 | 26.0 | 0.000 | |
Test Chemical | Allyl isovalerate | 25 | 50 | 1043 | 457 | 0.438 | 9.14 | 26.0 | -0.909 |
50 | 50 | 1038 | 446 | 0.430 | 8.92 | 26.0 | -2.828 | ||
100 | 50 | 1043 | 441 | 0.423 | 8.82 | 26.0 | -4.378 | ||
250 | 50 | 1039 | 986 | 0.949 | 19.72 | 31.0 | 114.618 | ||
500 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 2 | 50 | 1035 | 3489 | 3.371 | 69.78 | 26.0 | 662.368 |
Trend: | 14.644 | ||||||||
Probability: | 0.000 |