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Study Information
Study Attribute Value
CEBS Accession Number: 002-01634-0001-0000-7
Chemical Name: Allyl isovalerate
CASRN: 2835-39-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 286848_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Weakly Positive 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 11/09/1983    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1046 449 0.429 8.98 26.0 0.000
Negative (Not Specified)
0         
50 1044 424 0.406 8.48 26.0 -5.387
Test Chemical Allyl isovalerate
16         
50 1045 443 0.424 8.86 26.0 -1.242
50         
50 1041 457 0.439 9.14 26.0 2.271
160         
50 1047 482 0.460 9.64 26.0 7.247
500         
50 1040 640 0.615 12.80 26.0 43.361
Positive Control Mitomycin-C
 0.005     
50 1044 1472 1.410 29.44 26.0 228.468
Trend: 6.055        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/05/1983    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1024 395 0.386 7.90 26.0 -11.855
Dimethyl Sulfoxide
0         
50 1042 456 0.438 9.12 26.0 0.000
Test Chemical Allyl isovalerate
100         
50 1039 465 0.448 9.30 26.0 2.268
250         
50 1030 502 0.487 10.04 31.0 11.370
500         
50 1043 619 0.593 12.38 31.0 35.615
750         
50 1047 695 0.664 13.90 36.0 51.684
Positive Control Mitomycin-C
 0.003     
50 1036 1537 1.484 30.74 26.0 239.013
Trend: 8.220        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/09/1983    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1037 451 0.435 9.02 26.0 6.573
Dimethyl Sulfoxide
0         
50 1039 424 0.408 8.48 26.0 0.000
Test Chemical Allyl isovalerate
5         
50 1039 385 0.371 7.70 26.0 -9.198
16         
50 1038 435 0.419 8.70 26.0 2.693
50         
50 1026 446 0.435 8.92 26.0 6.521
160         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
1.5       
50 1043 1947 1.867 38.94 26.0 357.437
Trend: 1.441        
Probability: 0.075        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/05/1983    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1045 422 0.404 8.44 26.0 -8.673
Dimethyl Sulfoxide
0         
50 1029 455 0.442 9.10 26.0 0.000
Test Chemical Allyl isovalerate
25         
50 1043 457 0.438 9.14 26.0 -0.909
50         
50 1038 446 0.430 8.92 26.0 -2.828
100         
50 1043 441 0.423 8.82 26.0 -4.378
250         
50 1039 986 0.949 19.72 31.0 114.618
500         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
2         
50 1035 3489 3.371 69.78 26.0 662.368
Trend: 14.644        
Probability: 0.000