Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01634-0009-0000-5
Chemical Name:	Allyl isovalerate
CASRN:	2835-39-4
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	479203
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	82	113	131	53	47
			69	94	91	44
			75	103	87	39
			71	90	114	53
Test Chemical	Allyl isovalerate	50	84	105	149	59	55
			71	88	108	51	55
		100	61	90	86	47	55
			61	67	115	63	55
		200	84	48	177	70	67
			85	58	162	64	67
		400	62	15	206	112	164*
			56	6	360	216	164*
		800

Positive Control	Methyl Methane Sulfonate	20	26	19	371	479	537*
			21	13	366	595	537*
	Methyl Methane Sulfonate	250	70	79	532	255	274*
			59	69	517	293	274*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	92	106	95	35	26
			102	100	88	29
			95	104	64	23
			93	91	51	18
Test Chemical	Allyl isovalerate	100	96	48	144	50	48*
			81	43	113	46	48*
		200	89	27	109	41	49*
			91	30	154	57	49*
		300	68	10	119	58	53*
			71	11	103	48	53*
		400

Positive Control	Methyl Methane Sulfonate	20	31	11	227	248	229*
Positive Control			26	9	161	209	229*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination