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Study Information
Study Attribute Value
CEBS Accession Number: 002-01634-0009-0000-5
Chemical Name: Allyl isovalerate
CASRN: 2835-39-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 479203
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 82 113 131 53 47
    69 94 91 44
    75 103 87 39
    71 90 114 53
Test Chemical Allyl isovalerate 
50         
 84 105 149 59 55
    71 88 108 51
  
100         
 61 90 86 47 55
    61 67 115 63
  
200         
 84 48 177 70 67
    85 58 162 64
  
400         
 62 15 206 112 164*
    56 6 360 216
  
800         
   
Positive Control Methyl Methane Sulfonate 
20         
 26 19 371 479 537*
    21 13 366 595
Methyl Methane Sulfonate 
250         
 70 79 532 255 274*
    59 69 517 293

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 92 106 95 35 26
    102 100 88 29
    95 104 64 23
    93 91 51 18
Test Chemical Allyl isovalerate 
100         
 96 48 144 50 48*
    81 43 113 46
  
200         
 89 27 109 41 49*
    91 30 154 57
  
300         
 68 10 119 58 53*
    71 11 103 48
  
400         
   
Positive Control Methyl Methane Sulfonate 
20         
 31 11 227 248 229*
    26 9 161 209

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination