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Study Information
Study Attribute Value
CEBS Accession Number: 002-01646-0001-0000-0
Chemical Name: Amphotericin B
CASRN: 1397-89-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 995618_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/09/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 492 0.473 9.84 26.5 0.000
Test Chemical Amphotericin B 
1.96      
 50 1039 473 0.455 9.46 26.5 -3.677 
2.94      
 50 1039 519 0.500 10.38 26.5 5.691 
4.9       
 50 1034 602 0.582 12.04 30.5 23.186 
7.35      
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1040 653 0.628 13.06 26.5 32.851
Mitomycin-C 
 0.01      
 10 208 733 3.524 73.30 26.5 645.635
Trend: 3.854        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 09/23/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 416 0.398 8.32 26.5 0.000
Test Chemical Amphotericin B 
4         
 50 1033 446 0.432 8.92 26.5 8.457 
5         
 50 1045 378 0.362 7.56 26.5 -9.135 
6         
 50 1048 404 0.385 8.08 26.5 -3.163 
7         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 541 0.517 10.82 26.5 29.800
Mitomycin-C 
 0.01      
 10 210 651 3.100 65.10 26.5 678.726
Trend: -1.322        
Probability: 0.907        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/29/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 400 0.381 8.00 25.0 0.000
Test Chemical Amphotericin B 
1.49      
 50 1048 520 0.496 10.40 25.0 30.248 
4.97      
 50 1048 440 0.420 8.80 25.0 10.210 
14.9       
 50 1050 502 0.478 10.04 25.0 25.500 
49.7       
 50 1044 639 0.612 12.78 29.0 60.668
Positive Control Cyclophosphamide 
 0.4       
 50 1052 740 0.703 14.80 25.0 84.648
Cyclophosphamide 
2.5       
 10 211 472 2.237 47.20 25.0 487.204
Trend: 6.567        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/09/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 464 0.446 9.28 26.0 0.000
Test Chemical Amphotericin B 
14.7       
 50 1046 490 0.468 9.80 26.0 5.099 
19.6       
 50 1035 580 0.560 11.60 26.0 25.725 
29.4       
 50 1042 595 0.571 11.90 26.0 28.110 
39.2       
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1043 662 0.635 13.24 26.0 42.399
Cyclophosphamide 
2.5       
 10 209 220 1.053 22.00 26.0 136.162
Trend: 4.624        
Probability: 0.000