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Study Information
Study Attribute Value
CEBS Accession Number: 002-01646-0002-0000-1
Chemical Name: Amphotericin B
CASRN: 1397-89-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 995618_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/04/1986    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: Amphotericin B 
1.02      
 200 2 0.010 1.0 0 0.000 0.0 1 0.005 0.5 1 0.005 1.0 
3.06      
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
10.2       
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
15.3       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.3       
 200 40 0.200 12.0 9 0.045 3.5 21 0.105 9.0 10 0.050 1.0
Mitomycin-C 
5         
 25 33 1.320 52.0 13 0.520 44.0 10 0.400 20.0 10 0.400 1.0
Trend: -1.829 -0.621 -1.773  
Probability: 0.966 0.733 0.962  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/04/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: Amphotericin B 
10.2       
 200 8 0.040 3.5 2 0.010 1.0 5 0.025 2.5 1 0.005 1.0 
30.6       
 200 6 0.030 2.5 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
102         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 33 0.660 40.0 15 0.300 28.0 18 0.360 20.0 0 0.000 0.0
Trend: 0.102 -0.008 0.227  
Probability: 0.460 0.503 0.410  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/08/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.0 1 0.005 0.5 2 0.010 0.5 0 0.000 0.0
Test Chemical: Amphotericin B 
49.9       
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
99.5       
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0 
150         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
299         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 25 94 3.760 84.0 15 0.600 32.0 14 0.560 28.0 65 2.600 11.0
Trend: 0.702 -1.379 1.151  
Probability: 0.241 0.916 0.125