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Study Information
Study Attribute Value
CEBS Accession Number: 002-01654-0001-0000-9
Chemical Name: Aniline
CASRN: 62-53-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 997531_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/07/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 75 1571 879 0.560 11.72 26.0 0.000
Test Chemical Aniline 
16         
 50 1044 631 0.604 12.62 26.0 8.023 
50         
 50 1045 640 0.612 12.80 26.0 9.459 
160         
 50 1041 709 0.681 14.18 26.0 21.726
Positive Control Mitomycin-C 
 0.005     
 55 1150 1042 0.906 18.95 26.0 61.941
Trend: 3.773        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/01/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 427 0.407 8.54 26.0 0.000
Test Chemical Aniline 
50         
 50 1048 553 0.528 11.06 26.0 29.755 
160         
 50 1045 535 0.512 10.70 26.0 25.892 
500         
 50 1049 609 0.581 12.18 26.0 42.759
Positive Control Mitomycin-C 
 0.005     
 25 526 740 1.407 29.60 26.0 245.945
Trend: 5.146        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/07/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 492 0.469 9.84 26.0 0.000
Test Chemical Aniline 
160         
 50 1043 468 0.449 9.36 26.0 -4.422 
500         
 50 1044 540 0.517 10.80 26.0 10.177 
1600         
 50 1045 490 0.469 9.80 26.0 -0.121 
5000         
 50 1044 691 0.662 13.82 26.0 40.985
Positive Control Cyclophosphamide 
1         
 25 522 513 0.983 20.52 26.0 109.336
Trend: 5.767        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/15/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 451 0.430 9.02 26.0 0.000
Test Chemical Aniline 
3000         
 50 1050 526 0.501 10.52 26.0 16.630 
4000         
 50 1051 829 0.789 16.58 26.0 83.639 
5000         
 50 1050 759 0.723 15.18 26.0 68.293
Positive Control Cyclophosphamide 
1         
 50 1048 1117 1.066 22.34 26.0 148.144
Trend: 11.096        
Probability: 0.000