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Study Information
Study Attribute Value
CEBS Accession Number: 002-01654-0002-0000-0
Chemical Name: Aniline
CASRN: 62-53-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 997531_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 10/07/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Aniline 
160         
 100 6 0.060 5.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
500         
 100 8 0.080 5.0 2 0.020 2.0 6 0.060 3.0 0 0.000 0.0 
1600         
 100 7 0.070 6.0 2 0.020 2.0 5 0.050 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 17 0.340 28.0 6 0.120 12.0 11 0.220 18.0 0 0.000 0.0
Trend: 1.295 1.103 0.632  
Probability: 0.098 0.135 0.264  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/07/1982    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Aniline 
500         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
1600         
 100 8 0.080 8.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0 
5000         
 100 11 0.110 11.0 7 0.070 7.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 20 0.200 17.0 8 0.080 8.0 12 0.120 11.0 0 0.000 0.0
Trend: 2.540 2.354 1.222  
Probability: 0.006 0.009 0.111