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Study Information
Study Attribute Value
CEBS Accession Number: 002-01657-0001-0000-2
Chemical Name: Anthralin
CASRN: 1143-38-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 233146_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Test Failure 
No Activation  3  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/29/1985    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1016 456 0.449 9.12 26.0 0.000
Test Chemical Anthralin 
 0.017     
 50 1014 480 0.473 9.60 30.5 5.471 
 0.05      
 50 1029 502 0.488 10.04 30.5 8.697 
 0.17      
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1024 473 0.462 9.46 26.0 2.918
Mitomycin-C 
 0.01      
 5 102 200 1.961 40.00 26.0 336.877
Trend: 1.290        
Probability: 0.099        

Trial #: 2    Activation: No Activation    Date: 12/18/1985    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1020 426 0.418 8.52 26.0 0.000
Test Chemical Anthralin 
 0.025     
 50 1013 549 0.542 10.98 34.5 29.764 
 0.05      
 0 0 0 0.000 0.00 34.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1020 574 0.563 11.48 26.0 34.742
Mitomycin-C 
 0.01      
 5 103 175 1.699 35.00 26.0 306.810
Trend: 4.047        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 01/23/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1014 474 0.467 9.48 26.0 0.000
Test Chemical Anthralin 
 0.025     
 50 1020 434 0.425 8.68 26.0 -8.977 
 0.05      
 50 1026 460 0.448 9.20 26.0 -4.089 
 0.075     
 25 507 253 0.499 10.12 26.0 6.751 
 0.1       
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1011 595 0.589 11.90 26.0 25.900
Mitomycin-C 
 0.01      
 5 102 192 1.882 38.40 26.0 302.681
Trend: 0.632        
Probability: 0.264        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/29/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1007 442 0.439 8.84 26.0 0.000
Test Chemical Anthralin 
 0.017     
 50 1033 422 0.409 8.44 26.0 -6.928 
 0.05      
 50 1033 427 0.413 8.54 26.0 -5.825 
 0.17      
 50 1035 429 0.414 8.58 26.0 -5.567 
 0.5       
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1000 669 0.669 13.38 26.0 52.417
Cyclophosphamide 
2         
 5 99 168 1.697 33.60 26.0 286.617
Trend: -0.740        
Probability: 0.770