Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01657-0002-0000-3 |
Chemical Name: | Anthralin |
CASRN: | 1143-38-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 233146_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Acetone | 0 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Anthralin | 0.063 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
0.125 | 200 | 4 | 0.020 | 1.5 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | ||
0.19 | 200 | 6 | 0.030 | 2.5 | 0 | 0.000 | 0.0 | 6 | 0.030 | 2.5 | 0 | 0.000 | 0.0 | ||
0.25 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 63 | 0.315 | 24.5 | 29 | 0.145 | 13.0 | 34 | 0.170 | 13.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 17 | 0.680 | 36.0 | 6 | 0.240 | 24.0 | 11 | 0.440 | 28.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.064 | 0.585 | 0.933 | ||||||||||||
Probability: | 0.144 | 0.279 | 0.175 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 1.5 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Acetone | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Anthralin | 0.5 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
0.75 | 200 | 5 | 0.025 | 2.0 | 1 | 0.005 | 0.5 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 | ||
1 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 19 | 0.095 | 9.0 | 1 | 0.005 | 0.5 | 18 | 0.090 | 8.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 11 | 0.440 | 28.0 | 4 | 0.160 | 16.0 | 7 | 0.280 | 16.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.320 | 0.275 | 1.362 | ||||||||||||
Probability: | 0.093 | 0.391 | 0.087 |