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Study Information
Study Attribute Value
CEBS Accession Number: 002-01666-0001-0000-2
Chemical Name: Aroclor 1254
CASRN: 11097-69-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 207552_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/31/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 404 0.388 8.08 26.0 -2.183
Dimethyl Sulfoxide 
0         
 50 1045 415 0.397 8.30 26.0 0.000
Test Chemical Aroclor 1254 
 0.5       
 50 1042 439 0.421 8.78 26.0 6.088 
1.7       
 50 1045 434 0.415 8.68 26.0 4.578 
5         
 50 1042 448 0.430 8.96 26.0 8.263 
17         
 50 1043 457 0.438 9.14 26.0 10.332 
50         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 650 0.620 13.00 26.0 56.178
Mitomycin-C 
 0.005     
 10 209 273 1.306 27.30 26.0 228.916
Trend: 1.424        
Probability: 0.077        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/31/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1053 414 0.393 8.28 26.0 0.000
Negative (Not Specified) 
0         
 50 1048 408 0.389 8.16 26.0 -0.979
Test Chemical Aroclor 1254 
 0.5       
 50 1044 456 0.437 9.12 26.0 11.094 
1.7       
 50 1047 450 0.430 9.00 26.0 9.319 
5         
 50 1040 473 0.455 9.46 26.0 15.679 
17         
 50 1046 444 0.424 8.88 26.0 7.964 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1042 658 0.631 13.16 26.0 60.615
Cyclophosphamide 
 0.5       
 10 212 191 0.901 19.10 26.0 129.153
Trend: 1.248        
Probability: 0.106