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Study Information
Study Attribute Value
CEBS Accession Number: 002-01666-0003-0000-4
Chemical Name: Aroclor 1254
CASRN: 11097-69-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 783442_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 07/13/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 391 0.381 7.82 25.8 0.000
Test Chemical Aroclor 1254 
 0.5       
 50 1043 370 0.355 7.40 25.8 -6.913 
1.67      
 50 1044 381 0.365 7.62 25.8 -4.238 
5         
 15 308 178 0.578 11.87 25.8 51.649 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 748 0.715 14.96 25.8 87.647
Mitomycin-C 
 0.01      
 5 105 154 1.467 30.80 25.8 284.859
Trend: 2.811        
Probability: 0.002        

Trial #: 2    Activation: No Activation    Date: 07/28/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 524 210 0.401 8.40 25.8 0.000
Test Chemical Aroclor 1254 
3.75      
 25 522 252 0.483 10.08 25.8 20.460 
5         
 25 522 223 0.427 8.92 25.8 6.597 
12.5       
 25 519 264 0.509 10.56 25.8 26.925 
25         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 25 527 290 0.550 11.60 25.8 37.309
Mitomycin-C 
 0.01      
 5 105 183 1.743 36.60 25.8 334.884
Trend: 2.332        
Probability: 0.010        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/05/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 525 165 0.314 6.60 25.5 0.000
Test Chemical Aroclor 1254 
1.67      
 25 525 156 0.297 6.24 25.5 -5.455 
5         
 25 524 176 0.336 7.04 25.5 6.870 
16.7       
 25 524 209 0.399 8.36 25.5 26.908
Positive Control Cyclophosphamide 
 0.4       
 25 523 289 0.553 11.56 25.5 75.821
Cyclophosphamide 
2         
 5 105 177 1.686 35.40 25.5 436.364
Trend: 2.593        
Probability: 0.005        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/19/1987    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 525 170 0.324 6.80 25.5 0.000
Test Chemical Aroclor 1254 
12.5       
 25 525 197 0.375 7.88 25.5 15.882 
16.7       
 25 525 209 0.398 8.36 25.5 22.941 
20.9       
 25 524 199 0.380 7.96 25.5 17.282
Positive Control Cyclophosphamide 
 0.4       
 25 525 343 0.653 13.72 25.5 101.765
Cyclophosphamide 
2         
 5 105 215 2.048 43.00 25.5 532.353
Trend: 1.648        
Probability: 0.050