Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01666-0004-0000-5 |
Chemical Name: | Aroclor 1254 |
CASRN: | 11097-69-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 783442_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Aroclor 1254 | 9 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
12 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.25 | 200 | 27 | 0.135 | 11.5 | 17 | 0.085 | 8.0 | 10 | 0.050 | 4.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.75 | 25 | 12 | 0.480 | 28.0 | 6 | 0.240 | 16.0 | 6 | 0.240 | 20.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.000 | 0.000 | 0.000 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Aroclor 1254 | 12 | 200 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
18 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
24 | 200 | 7 | 0.035 | 3.5 | 4 | 0.020 | 2.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 19 | 0.095 | 9.5 | 2 | 0.010 | 1.0 | 17 | 0.085 | 8.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 9 | 0.360 | 32.0 | 7 | 0.280 | 28.0 | 2 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | |
Trend: | 2.186 | 1.790 | 1.245 | ||||||||||||
Probability: | 0.014 | 0.037 | 0.107 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Aroclor 1254 | 12 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
24 | 77 | 1 | 0.013 | 1.3 | 1 | 0.013 | 1.3 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
36 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 65 | 0.325 | 21.0 | 42 | 0.210 | 17.0 | 23 | 0.115 | 9.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 15 | 0.600 | 40.0 | 9 | 0.360 | 28.0 | 6 | 0.240 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.664 | 1.865 | -0.508 | ||||||||||||
Probability: | 0.253 | 0.031 | 0.694 |