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Study Information
Study Attribute Value
CEBS Accession Number: 002-01666-0010-0000-2
Chemical Name: Aroclor 1254
CASRN: 11097-69-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 166234_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/26/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0002
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 6.00 ± 1.60 0.0000
Test Chemical Aroclor 1254 
1250         
 8 1.00 ± 0.53 0.2555
  
2500         
 8 1.50 ± 0.63 0.1084
  
5000         
 8 3.75 ± 1.33 0.0018
Vehicle Control No Stressor 
 0         
 7 0.57 ± 0.57 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/07/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.4326
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 3.50 ± 0.98 0.0012
Test Chemical Aroclor 1254 
1250         
 8 1.75 ± 1.22 0.0469
  
2500         
 8 0.75 ± 0.37 0.3269
  
5000         
 8 1.00 ± 0.53 0.2062
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.50 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/06/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9529
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 3.00 ± 1.07 0.0217
Test Chemical Aroclor 1254 
1250         
 8 2.50 ± 0.91 0.0529
  
2500         
 8 1.25 ± 0.65 0.3687
  
5000         
 8 0.25 ± 0.25 0.9108
Vehicle Control No Stressor 
 0         
 8 0.89 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/20/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.3057
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 12.25 ± 1.44 0.0000
  
200         
 8 15.50 ± 2.20 0.0000
Test Chemical Aroclor 1254 
1250         
 8 1.00 ± 0.53 0.5000
  
2500         
 8 2.25 ± 0.70 0.0810
  
5000         
 8 1.25 ± 0.65 0.3687
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.76 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed