COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01666-0010-0000-2
Chemical Name: Aroclor 1254
CASRN: 11097-69-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 166234_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/26/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0002
Test Group Dose
(mg/kg)
n Percent Cells w/ Aberrations
(Mean ± SEM)
Pairwise P
Positive Control Dimethylbenzanthracene
100         
8 6.00 ± 1.60 0.0000
Test Chemical Aroclor 1254
1250         
8 1.00 ± 0.53 0.2555
 
2500         
8 1.50 ± 0.63 0.1084
 
5000         
8 3.75 ± 1.33 0.0018
Vehicle Control No Stressor
 0         
7 0.57 ± 0.57 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/07/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.4326
Test Group Dose
(mg/kg)
n Percent Cells w/ Aberrations
(Mean ± SEM)
Pairwise P
Positive Control Dimethylbenzanthracene
100         
8 3.50 ± 0.98 0.0012
Test Chemical Aroclor 1254
1250         
8 1.75 ± 1.22 0.0469
 
2500         
8 0.75 ± 0.37 0.3269
 
5000         
8 1.00 ± 0.53 0.2062
Vehicle Control No Stressor
 0         
8 0.50 ± 0.50 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/06/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9529
Test Group Dose
(mg/kg)
n Percent Cells w/ Aberrations
(Mean ± SEM)
Pairwise P
Positive Control Dimethylbenzanthracene
100         
8 3.00 ± 1.07 0.0217
Test Chemical Aroclor 1254
1250         
8 2.50 ± 0.91 0.0529
 
2500         
8 1.25 ± 0.65 0.3687
 
5000         
8 0.25 ± 0.25 0.9108
Vehicle Control No Stressor
 0         
8 0.89 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/20/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.3057
Test Group Dose
(mg/kg)
n Percent Cells w/ Aberrations
(Mean ± SEM)
Pairwise P
Positive Control Dimethylbenzanthracene
100         
8 12.25 ± 1.44 0.0000
 
200         
8 15.50 ± 2.20 0.0000
Test Chemical Aroclor 1254
1250         
8 1.00 ± 0.53 0.5000
 
2500         
8 2.25 ± 0.70 0.0810
 
5000         
8 1.25 ± 0.65 0.3687
Vehicle Control No Stressor
 0         
8 1.00 ± 0.76 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed