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Study Information
Study Attribute Value
CEBS Accession Number: 002-01675-0001-0000-2
Chemical Name: Azinphosmethyl
CASRN: 86-50-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 930409_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/17/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1036 394 0.380 7.88 26.0 -1.120
Dimethyl Sulfoxide 
0         
 50 1053 405 0.385 8.10 26.0 0.000
Test Chemical Azinphosmethyl 
2.5       
 50 1042 393 0.377 7.86 26.0 -1.939 
8.3       
 50 1051 515 0.490 10.30 26.0 27.402 
25         
 50 1047 705 0.673 14.10 26.0 75.072 
83         
 0 0 0 0.000 0.00 0.0 N/A 
250         
 0 0 0 0.000 0.00 0.0 N/A 
833         
 0 0 0 0.000 0.00 0.0 N/A 
2500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1043 556 0.533 11.12 26.0 38.600
Mitomycin-C 
 0.004     
 10 209 191 0.914 19.10 26.0 137.608
Trend: 10.174        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 09/12/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 410 0.390 8.20 26.0 0.000
Negative (Not Specified) 
0         
 50 1048 394 0.376 7.88 26.0 -3.536
Test Chemical Azinphosmethyl 
6.3       
 50 1048 439 0.419 8.78 26.0 7.482 
13         
 50 1047 530 0.506 10.60 26.0 29.886 
25         
 50 1044 551 0.528 11.02 26.0 35.420 
50         
 0 0 0 0.000 0.00 0.0 N/A 
100         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1051 686 0.653 13.72 26.0 67.476
Mitomycin-C 
 0.004     
 10 211 188 0.891 18.80 26.0 128.616
Trend: 5.370        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/17/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 390 0.372 7.80 26.0 0.000
Negative (Not Specified) 
0         
 50 1053 424 0.403 8.48 26.0 8.202
Test Chemical Azinphosmethyl 
8.3       
 50 1054 419 0.398 8.38 26.0 6.824 
25         
 50 1044 476 0.456 9.52 26.0 22.519 
83         
 50 1044 554 0.531 11.08 26.0 42.596 
250         
 0 0 0 0.000 0.00 0.0 N/A 
833         
 0 0 0 0.000 0.00 0.0 N/A 
2500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1050 567 0.540 11.34 26.0 45.108
Cyclophosphamide 
 0.5       
 10 210 241 1.148 24.10 26.0 208.386
Trend: 5.840        
Probability: 0.000