Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01675-0002-0000-3 |
Chemical Name: | Azinphosmethyl |
CASRN: | 86-50-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 930409_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
Induced Rat Liver S9 | 1_S9 | Weakly Positive* |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Azinphosmethyl | 22 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
47 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
100 | 200 | 6 | 0.030 | 3.0 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | ||
Positive Control: | Mitomycin-C | 0.4 | 25 | 17 | 0.680 | 52.0 | 14 | 0.560 | 44.0 | 3 | 0.120 | 12.0 | 0 | 0.000 | 0.0 |
Trend: | 2.859 | 2.241 | 1.292 | ||||||||||||
Probability: | 0.002 | 0.013 | 0.098 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Azinphosmethyl | 32 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
70 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
150 | 50 | 39 | 0.780 | 58.0 | 13 | 0.260 | 20.0 | 26 | 0.520 | 40.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 13 | 0.520 | 40.0 | 11 | 0.440 | 36.0 | 2 | 0.080 | 8.0 | 0 | 0.000 | 0.0 |
Trend: | 8.885 | 4.991 | 7.474 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Azinphosmethyl | 125 | 200 | 43 | 0.215 | 15.5 | 29 | 0.145 | 12.5 | 14 | 0.070 | 5.0 | 0 | 0.000 | 0.0 |
150 | 100 | 50 | 0.500 | 25.0 | 26 | 0.260 | 20.0 | 24 | 0.240 | 13.0 | 0 | 0.000 | 0.0 | ||
175 | 50 | 76 | 1.520 | 50.0 | 29 | 0.580 | 36.0 | 37 | 0.740 | 34.0 | 10 | 0.200 | 2.0 | ||
200 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 21 | 0.840 | 40.0 | 15 | 0.600 | 28.0 | 6 | 0.240 | 16.0 | 0 | 0.000 | 0.0 |
Trend: | 9.242 | 7.631 | 8.086 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |