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Study Information
Study Attribute Value
CEBS Accession Number: 002-01675-0002-0000-3
Chemical Name: Azinphosmethyl
CASRN: 86-50-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 930409_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Weakly Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 08/24/1989    Harvest Time: 16 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Azinphosmethyl
22         
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
47         
200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
100         
200 6 0.030 3.0 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5
Positive Control: Mitomycin-C
 0.4       
25 17 0.680 52.0 14 0.560 44.0 3 0.120 12.0 0 0.000 0.0
Trend: 2.859 2.241 1.292  
Probability: 0.002 0.013 0.098  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/24/1989    Harvest Time: 15 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Negative (Not Specified)
0         
200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Azinphosmethyl
32         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
70         
200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
150         
50 39 0.780 58.0 13 0.260 20.0 26 0.520 40.0 0 0.000 0.0
Positive Control: Cyclophosphamide
20         
25 13 0.520 40.0 11 0.440 36.0 2 0.080 8.0 0 0.000 0.0
Trend: 8.885 4.991 7.474  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/24/1989    Harvest Time: 15 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Azinphosmethyl
125         
200 43 0.215 15.5 29 0.145 12.5 14 0.070 5.0 0 0.000 0.0
150         
100 50 0.500 25.0 26 0.260 20.0 24 0.240 13.0 0 0.000 0.0
175         
50 76 1.520 50.0 29 0.580 36.0 37 0.740 34.0 10 0.200 2.0
200         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
20         
25 21 0.840 40.0 15 0.600 28.0 6 0.240 16.0 0 0.000 0.0
Trend: 9.242 7.631 8.086  
Probability: 0.000 0.000 0.000