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Study Information
Study Attribute Value
CEBS Accession Number: 002-01677-0003-0000-6
Chemical Name: Azobenzene
CASRN: 103-33-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 758475_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/28/1980    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 361 0.344 7.22 26.0 0.000
Test Chemical Azobenzene 
 0.003     
 50 1051 428 0.407 8.56 26.0 18.447 
 0.025     
 50 1045 382 0.366 7.64 26.0 6.323 
 0.25      
 50 1049 409 0.390 8.18 26.0 13.404 
2.5       
 50 1044 396 0.379 7.92 26.0 10.326 
25         
 50 1046 444 0.424 8.88 26.0 23.462
Positive Control Triethylenemelamine 
 0.025     
 50 1048 1826 1.742 36.52 26.0 406.782
Trend: 2.160        
Probability: 0.015        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/28/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 348 0.335 6.96 26.0 0.000
Test Chemical Azobenzene 
 0.003     
 50 1050 412 0.392 8.24 26.0 17.151 
 0.025     
 50 1049 421 0.401 8.42 26.0 19.824 
 0.25      
 50 1049 413 0.394 8.26 26.0 17.547 
2.5       
 50 1047 454 0.434 9.08 26.0 29.463 
25         
 19 397 214 0.539 11.26 26.0 60.938
Positive Control Cyclophosphamide 
1.5       
 50 1049 1970 1.878 39.40 26.0 460.695
Trend: 5.001        
Probability: 0.000