Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01677-0004-0000-7 |
Chemical Name: | Azobenzene |
CASRN: | 103-33-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 758475_CA |
Study Result: | Equivocal |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Questionable |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Azobenzene | 0.003 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
0.025 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
0.25 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | ||
2.5 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
25 | 100 | 6 | 0.060 | 6.0 | 2 | 0.020 | 2.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Triethylenemelamine | 0.25 | 100 | 52 | 0.520 | 36.0 | 18 | 0.180 | 17.0 | 34 | 0.340 | 24.0 | 0 | 0.000 | 0.0 |
Trend: | 0.288 | -0.368 | 0.488 | ||||||||||||
Probability: | 0.387 | 0.644 | 0.313 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Azobenzene | 0.003 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
0.025 | 100 | 4 | 0.040 | 3.0 | 2 | 0.020 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
0.25 | 100 | 8 | 0.080 | 7.0 | 3 | 0.030 | 3.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | ||
2.5 | 100 | 6 | 0.060 | 5.0 | 2 | 0.020 | 2.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
25 | 125 | 14 | 0.112 | 11.0 | 3 | 0.024 | 2.0 | 7 | 0.056 | 5.0 | 4 | 0.032 | 3.0 | ||
Positive Control: | Cyclophosphamide | 25 | 100 | 61 | 0.610 | 37.0 | 27 | 0.270 | 23.0 | 31 | 0.310 | 23.0 | 3 | 0.030 | 3.0 |
Trend: | 3.262 | 1.851 | 1.521 | ||||||||||||
Probability: | 0.001 | 0.032 | 0.064 |