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Study Information
Study Attribute Value
CEBS Accession Number: 002-01677-0004-0000-7
Chemical Name: Azobenzene
CASRN: 103-33-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 758475_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 

Trial #:1   Activation: No Activation    Date: 08/28/1980    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Azobenzene 
 0.003     
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
 0.025     
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
 0.25      
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0 
2.5       
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
25         
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 100 52 0.520 36.0 18 0.180 17.0 34 0.340 24.0 0 0.000 0.0
Trend: 0.288 -0.368 0.488  
Probability: 0.387 0.644 0.313  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/28/1980    Harvest Time: 14 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Azobenzene 
 0.003     
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
 0.025     
 100 4 0.040 3.0 2 0.020 1.0 2 0.020 2.0 0 0.000 0.0 
 0.25      
 100 8 0.080 7.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0 
2.5       
 100 6 0.060 5.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
25         
 125 14 0.112 11.0 3 0.024 2.0 7 0.056 5.0 4 0.032 3.0
Positive Control: Cyclophosphamide 
25         
 100 61 0.610 37.0 27 0.270 23.0 31 0.310 23.0 3 0.030 3.0
Trend: 3.262 1.851 1.521  
Probability: 0.001 0.032 0.064