COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01684-0001-0000-2
Chemical Name: Barium chloride dihydrate
CASRN: 10326-27-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 384673_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/17/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1026 390 0.380 7.80 27.0 7.058
Water 
0         
 50 1028 365 0.355 7.30 27.0 0.000
Test Chemical Barium chloride dihydrate 
50         
 50 1031 365 0.354 7.30 27.0 -0.291 
160         
 50 1027 399 0.389 7.98 27.0 9.422 
500         
 50 1040 388 0.373 7.76 27.0 5.075 
1600         
 50 1019 407 0.399 8.14 27.0 12.492 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.003     
 50 1030 1024 0.994 20.48 27.0 180.003
Mitomycin-C 
 0.005     
 50 1039 1461 1.406 29.22 27.0 296.036
Trend: 1.785        
Probability: 0.037        

Trial #: 2    Activation: No Activation    Date: 07/19/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1045 357 0.342 7.14 27.0 0.000
Negative (Not Specified) 
0         
 50 1040 340 0.327 6.80 27.0 -4.304
Test Chemical Barium chloride dihydrate 
100         
 50 1038 353 0.340 7.06 27.0 -0.454 
250         
 50 1038 405 0.390 8.10 27.0 14.210 
500         
 50 1030 407 0.395 8.14 27.0 15.666 
1000         
 50 1040 358 0.344 7.16 27.0 0.762 
1500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1039 1188 1.143 23.76 27.0 234.695
Trend: 1.137        
Probability: 0.128        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/17/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1030 384 0.373 7.68 27.0 0.000
Negative (Not Specified) 
0         
 50 1044 402 0.385 8.04 27.0 3.284
Test Chemical Barium chloride dihydrate 
50         
 50 1031 358 0.347 7.16 27.0 -6.861 
160         
 50 1042 406 0.390 8.12 27.0 4.512 
500         
 50 1042 393 0.377 7.86 27.0 1.165 
1600         
 50 1029 397 0.386 7.94 27.0 3.486 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1034 1338 1.294 26.76 27.0 247.090
Trend: 0.930        
Probability: 0.176        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/13/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 420 0.403 8.40 26.0 10.898
Water 
0         
 50 1041 378 0.363 7.56 26.0 0.000
Test Chemical Barium chloride dihydrate 
500         
 50 1033 363 0.351 7.26 26.0 -3.225 
750         
 50 1029 363 0.353 7.26 26.0 -2.848 
1600         
 50 1040 359 0.345 7.18 26.0 -4.935 
3000         
 50 1035 377 0.364 7.54 26.0 0.314 
4000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1035 1686 1.629 33.72 26.0 348.617
Trend: -0.030        
Probability: 0.512