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Study Information
Study Attribute Value
CEBS Accession Number: 002-01688-0010-0000-6
Chemical Name: Benzaldehyde
CASRN: 100-52-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 895369
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 58 100 99 57 52
    81 95 122 51
    84 104 122 48
Test Chemical Benzaldehyde 
50         
 72 92 105 49 50
    60 101 92 51
  
100         
 80 101 124 51 51
    90 103 136 51
  
200         
 59 65 121 69 62
    80 94 130 54
  
400         
 68 51 406 200 185*
    78 59 401 171
  
800         
   
Positive Control Methyl Methane Sulfonate 
15         
 54 27 392 240 247*
    45 32 339 254

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 60 87 111 62 53
    76 108 104 46
    70 110 111 53
    74 95 113 51
Test Chemical Benzaldehyde 
80         
 75 81 113 50 47
    91 92 140 52
    59 70 71 40
  
160         
 66 78 99 50 57
    89 80 163 61
    80 74 142 59
  
320         
 76 38 168 74 71
    92 40 161 58
    75 30 184 81
  
480         
 50 10 168 112 98*
    82 13 203 82
    63 17 188 100
  
640         
   
   
Positive Control Methyl Methane Sulfonate 
15         
 21 15 187 297 314*
    18 12 176 332

Nonactivation Trial: 3 Experiment Call: Rejected
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 101 99 125 41 44
    95 103 122 43
    84 99 118 47
    123r 112 121 33
Test Chemical Benzaldehyde 
350         
 116 69 134 39 49
    140r 69 176 42
    90 66 158 59
  
400         
 125r 53 151 40
    127r 52 139 37
    68 47 157 77
  
450         
 122r 48 174 48 33
    97 54 97 34
    87 44 85 33
  
500         
 53 29 114 72 55
    90 47 115 43
    81 48 123 51
Positive Control Methyl Methane Sulfonate 
15         
 35 21 389 372 348*
    42 25 407 323

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination