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Study Information
Study Attribute Value
CEBS Accession Number: 002-01690-0001-0000-9
Chemical Name: Benzene
CASRN: 71-43-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 603980_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/04/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1036 439 0.424 8.78 26.0 -2.032
Dimethyl Sulfoxide 
0         
 50 1045 452 0.433 9.04 26.0 0.000
Test Chemical Benzene 
16         
 50 1044 447 0.428 8.94 26.0 -1.011 
50         
 50 1029 423 0.411 8.46 26.0 -4.961 
160         
 50 1040 461 0.443 9.22 26.0 2.481 
500         
 50 1032 432 0.419 8.64 26.0 -3.221 
1600         
 0 0 0 0.000 0.00 0.0 N/A 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1033 1825 1.767 36.50 26.0 308.451
Trend: -0.195        
Probability: 0.577        

Trial #: 2    Activation: No Activation    Date: 12/04/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 383 0.367 7.66 26.0 -4.635
Dimethyl Sulfoxide 
0         
 50 1044 402 0.385 8.04 26.0 0.000
Test Chemical Benzene 
100         
 50 1024 413 0.403 8.26 26.0 4.743 
250         
 50 1035 422 0.408 8.44 26.0 5.888 
500         
 50 1031 463 0.449 9.26 26.0 16.626 
750         
 50 1020 502 0.492 10.04 26.0 27.814 
1000         
 50 1029 534 0.519 10.68 26.0 34.772
Positive Control Mitomycin-C 
 0.01      
 50 1045 2018 1.931 40.36 26.0 401.510
Trend: 5.392        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/04/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 398 0.382 7.96 26.0 0.000
Negative (Not Specified) 
0         
 50 1028 439 0.427 8.78 26.0 11.804
Test Chemical Benzene 
16         
 50 1029 409 0.397 8.18 26.0 4.062 
50         
 50 1039 437 0.421 8.74 26.0 10.116 
160         
 50 1048 419 0.400 8.38 26.0 4.674 
500         
 50 1043 439 0.421 8.78 26.0 10.196 
1600         
 50 1038 460 0.443 9.20 26.0 16.023 
5000         
 50 1036 445 0.430 8.90 26.0 12.457
Positive Control Cyclophosphamide 
1.5       
 50 1044 1562 1.496 31.24 26.0 291.710
Trend: 2.220        
Probability: 0.013