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Study Information
Study Attribute Value
CEBS Accession Number: 002-01690-0019-0000-8
Chemical Name: Benzene
CASRN: 71-43-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 867104_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/18/87 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.02 ± 0.499
Test Chemical Benzene 
950         
 4 5.95 ± 0.458
  
1900         
 4 5.64 ± 0.870
  
3800         
 4 8.36 ± 0.322
Positive Control Dimethylbenzanthracene 
2.5       
 4 5.81 ± 0.420


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/12/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.48 ± 0.575
Test Chemical Benzene 
950         
 4 9.47 ± 0.516
  
1900         
 4 8.77 ± 1.588
  
3800         
 3 11.90 ± 2.904
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.33 ± 0.593


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed