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Study Information
Study Attribute Value
CEBS Accession Number: 002-01690-0020-0000-0
Chemical Name: Benzene
CASRN: 71-43-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 867104_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 11/25/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1172
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 17.50 ± 1.40 0.0000
Test Chemical Benzene 
1000         
 8 9.25 ± 3.18 0.0001
  
2000         
 8 8.25 ± 2.81 0.0003
  
4000         
 8 6.25 ± 1.58 0.0085
Vehicle Control No Stressor 
 0         
 8 2.75 ± 0.65 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/05/90 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0050
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 20.75 ± 4.32 0.0000
Test Chemical Benzene 
850         
 8 2.50 ± 0.82 0.4082
  
1700         
 8 2.75 ± 0.92 0.3253
  
3400         
 8 5.25 ± 1.85 0.0128
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.59 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/17/90 35 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 35 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 7 34.29 ± 4.03 0.0000
Test Chemical Benzene 
1700         
 8 2.00 ± 0.65 0.3972
  
2550         
 8 2.75 ± 0.75 0.1701
  
3400         
 8 8.25 ± 2.25 0.0000
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.59 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed