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Study Information
Study Attribute Value
CEBS Accession Number: 002-01693-0001-0000-2
Chemical Name: Benzethonium chloride
CASRN: 121-54-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 173525_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/31/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1047 434 0.415 8.68 26.0 0.000
Test Chemical Benzethonium chloride 
 0.96      
 50 1049 458 0.437 9.16 26.0 5.329 
3         
 50 1050 457 0.435 9.14 26.0 4.999 
9.6       
 50 1048 473 0.451 9.46 26.0 8.882
Positive Control Mitomycin-C 
 0.005     
 25 523 639 1.222 25.56 26.0 194.752
Trend: 1.199        
Probability: 0.115        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/31/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1043 369 0.354 7.38 26.0 0.000
Test Chemical Benzethonium chloride 
3         
 50 1048 347 0.331 6.94 26.0 -6.411 
9.6       
 50 1050 359 0.342 7.18 26.0 -3.359 
30         
 50 1047 367 0.351 7.34 26.0 -0.922
Positive Control Cyclophosphamide 
1         
 50 1045 790 0.756 15.80 26.0 113.682
Trend: 0.013        
Probability: 0.495