| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01694-0015-0000-8 |
| Chemical Name: | Benzidine dihydrochloride |
| CASRN: | 531-85-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 758694_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 03/20/85 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 3.37 ± 0.432 | |
| Test Chemical | Benzidine dihydrochloride | 50 | 4 | 6.12 ± 0.563 | |
100 | 4 | 6.21 ± 0.522 | |||
200 | 4 | 6.73 ± 0.605 | |||
| Positive Control | Dimethylbenzanthracene | 100 | 4 | 13.27 ± 0.951 | |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 02/10/87 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 4.37 ± 0.655 | |
| Test Chemical | Benzidine dihydrochloride | 50 | 4 | 7.44 ± 0.995 | |
100 | 4 | 6.90 ± 0.266 | |||
200 | 4 | 9.83 ± 1.236 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 9.84 ± 0.710 | |
Footnotes: IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed