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Study Information
Study Attribute Value
CEBS Accession Number: 002-01694-0016-0000-9
Chemical Name: Benzidine dihydrochloride
CASRN: 531-85-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 758694_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/28/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.7601
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 16.75 ± 1.89 0.0000
Test Chemical Benzidine dihydrochloride 
50         
 8 5.00 ± 1.07 0.0314
  
100         
 8 4.50 ± 1.18 0.0619
  
200         
 8 2.25 ± 0.80 0.5918
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.73 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/21/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.3586
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 19.75 ± 1.98 0.0000
Test Chemical Benzidine dihydrochloride 
50         
 8 0.75 ± 0.37 0.9355
  
100         
 8 3.50 ± 1.12 0.0973
  
200         
 8 1.75 ± 0.70 0.6028
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.76 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/24/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0022
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 23.50 ± 2.03 0.0000
Test Chemical Benzidine dihydrochloride 
50         
 8 3.75 ± 0.88 0.0419
  
100         
 8 2.75 ± 0.65 0.1701
  
200         
 8 5.75 ± 2.05 0.0015
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.80 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/14/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0027
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 23.25 ± 3.68 0.0000
Test Chemical Benzidine dihydrochloride 
100         
 8 4.25 ± 0.59 0.4294
  
150         
 8 4.25 ± 1.10 0.4294
  
200         
 8 9.25 ± 3.18 0.0014
Vehicle Control No Stressor 
 0         
 8 4.00 ± 1.13 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed