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Study Information
Study Attribute Value
CEBS Accession Number: 002-01698-0001-0000-7
Chemical Name: Benzo(a)pyrene
CASRN: 50-32-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 994593_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/23/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 368 0.351 7.36 26.0 -9.433
Dimethyl Sulfoxide 
0         
 50 1041 404 0.388 8.08 26.0 0.000
Test Chemical Benzo(a)pyrene 
5         
 50 1048 399 0.381 7.98 26.0 -1.897 
15         
 50 1043 453 0.434 9.06 26.0 11.914 
50         
 50 1049 420 0.400 8.40 26.0 3.168 
150         
 50 1042 403 0.387 8.06 26.0 -0.343
Positive Control Mitomycin-C 
 0.001     
 50 1049 603 0.575 12.06 26.0 48.119
Mitomycin-C 
 0.005     
 10 210 255 1.214 25.50 26.0 212.889
Trend: 0.259        
Probability: 0.398        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/23/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 379 0.363 7.58 26.0 -0.096
Dimethyl Sulfoxide 
0         
 50 1044 379 0.363 7.58 26.0 0.000
Test Chemical Benzo(a)pyrene 
5         
 50 1043 913 0.875 18.26 26.0 141.128 
15         
 50 1040 1273 1.224 25.46 26.0 237.176 
50         
 50 1043 1356 1.300 27.12 26.0 258.127 
150         
 50 1039 1557 1.499 31.14 26.0 312.795
Positive Control Cyclophosphamide 
 0.125     
 50 1038 594 0.572 11.88 26.0 57.634
Cyclophosphamide 
 0.5       
 10 206 191 0.927 19.10 26.0 155.404
Trend: 26.780        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/06/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1051 427 0.406 8.54 26.0 4.615
Dimethyl Sulfoxide 
0         
 50 1048 407 0.388 8.14 26.0 0.000
Test Chemical Benzo(a)pyrene 
5         
 50 1041 1223 1.175 24.46 26.0 202.512 
15         
 50 1035 1468 1.418 29.36 31.0 265.218 
50         
 50 1043 1686 1.616 33.72 31.0 316.236 
150         
 50 1038 1607 1.548 32.14 31.0 298.644
Positive Control Cyclophosphamide 
 0.125     
 50 1047 575 0.549 11.50 26.0 41.413
Cyclophosphamide 
 0.5       
 10 211 229 1.085 22.90 26.0 179.460
Trend: 25.473        
Probability: 0.000