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Study Information
Study Attribute Value
CEBS Accession Number: 002-01698-0002-0000-8
Chemical Name: Benzo(a)pyrene
CASRN: 50-32-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 994593_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 11/28/1988    Harvest Time: 15.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 2.0 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0
Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Benzo(a)pyrene 
32         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
70         
 200 2 0.010 0.5 0 0.000 0.0 2 0.010 0.5 0 0.000 0.0 
150         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.1       
 200 66 0.330 25.0 43 0.215 18.0 23 0.115 10.5 0 0.000 0.0
Mitomycin-C 
 0.4       
 50 30 0.600 40.0 14 0.280 20.0 16 0.320 24.0 0 0.000 0.0
Trend: -0.322 0.770 -1.003  
Probability: 0.626 0.221 0.842  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/08/1988    Harvest Time: 17.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Benzo(a)pyrene 
32         
 50 49 0.980 52.0 34 0.680 44.0 15 0.300 26.0 0 0.000 0.0 
70         
 50 55 1.100 54.0 33 0.660 44.0 12 0.240 24.0 10 0.200 1.0 
150         
 50 53 1.060 52.0 42 0.840 46.0 11 0.220 18.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 98 0.490 33.5 63 0.315 26.5 35 0.175 13.5 0 0.000 0.0
Cyclophosphamide 
15         
 50 94 1.880 70.0 59 1.180 66.0 25 0.500 36.0 10 0.200 1.0
Trend: 7.051 6.689 3.218  
Probability: 0.000 0.000 0.001  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 11/28/1988    Harvest Time: 17.2 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 0 0.000 0.0 4 0.040 3.0 0 0.000 0.0
Test Chemical: Benzo(a)pyrene 
32         
 50 30 0.600 36.0 20 0.400 32.0 10 0.200 18.0 0 0.000 0.0 
70         
 50 43 0.860 56.0 32 0.640 50.0 11 0.220 18.0 0 0.000 0.0 
150         
 50 35 0.700 52.0 18 0.360 32.0 17 0.340 26.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 79 0.395 26.0 46 0.230 19.0 33 0.165 12.0 0 0.000 0.0
Cyclophosphamide 
15         
 50 75 1.500 62.0 49 0.980 50.0 26 0.520 34.0 0 0.000 0.0
Trend: 7.346 5.909 3.985  
Probability: 0.000 0.000 0.000