Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01700-0002-0000-2 |
Chemical Name: | Benzo(e)pyrene |
CASRN: | 192-97-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | G17917 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 68 | 105 | 66 | 32 | 36 |
65 | 82 | 76 | 39 | ||||
Test Chemical | Benzo(e)pyrene | 15.6 | 69 | 77 | 96 | 47 | 38 |
103 | 132 | 93 | 30 | ||||
31.25 | 62 | 82 | 93 | 50 | 49 | ||
76 | 91 | 107 | 47 | ||||
62.5 | 80 | 99 | 106 | 44 | 38 | ||
76 | 95 | 71 | 31 | ||||
125 | 89 | 96 | 71 | 27 | 32 | ||
85 | 91 | 96 | 38 | ||||
250 | 74 | 77 | 96 | 43 | 40 | ||
76 | 86 | 84 | 37 | ||||
Positive Control | Ethyl Methane Sulfonate | 500 | 36 | 18 | 758 | 705 | 658* |
46 | 30 | 838 | 612 | ||||
Negative Control | Negative (Not Specified) | 0 | 105 | 117 | 130 | 41 | 36* |
72 | 96 | 67 | 31 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 85 | 93 | 142 | 56 | 57 |
89 | 102 | 154 | 57 | ||||
Test Chemical | Benzo(e)pyrene | 15.6 | 74 | 93 | 128 | 58 | 59 |
68 | 81 | 123 | 60 | ||||
31.25 | 97 | 97 | 165 | 57 | 59 | ||
78 | 90 | 144 | 61 | ||||
62.5 | 73 | 107 | 104 | 47 | 53 | ||
73 | 79 | 126 | 58 | ||||
125 | 82 | 82 | 102 | 42 | 51 | ||
72 | 77 | 129 | 60 | ||||
250 | 75r | 92 | 92 | 41 | |||
Positive Control | Ethyl Methane Sulfonate | 500 | 77 | 54 | 974 | 422 | 459* |
63 | 51 | 931 | 497 | ||||
Negative Control | Negative (Not Specified) | 0 | 67 | 102 | 125 | 63 | 60* |
86 | 104 | 147 | 57 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 91 | 108 | 46 | 17 | 19 |
90 | 86 | 59 | 22 | ||||
Test Chemical | Benzo(e)pyrene | 15 | 79 | 68 | 89 | 38 | 48* |
59# | 37 | 105 | 59 | ||||
30 | 66 | 34 | 77 | 39 | 44* | ||
51 | 35 | 75 | 49 | ||||
60 | 78 | 74 | 94 | 40 | 41* | ||
61 | 48 | 76 | 41 | ||||
80 | 62 | 55 | 78 | 42 | 43* | ||
53# | 54 | 70.5 | 45 | ||||
100 | 65 | 57 | 86 | 44 | 47* | ||
64 | 44 | 94 | 49 | ||||
Positive Control | 3-Methylcholanthrene | 7 | 80 | 49 | 297 | 124 | 128* |
83 | 57 | 330 | 132 | ||||
Negative Control | Negative (Not Specified) | 0 | 85 | 100 | 63 | 25 | 27* |
66 | 106 | 56 | 28 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 72 | 92 | 187 | 86 | 93 |
83 | 94 | 247 | 99 | ||||
Test Chemical | Benzo(e)pyrene | 31.3 | 73 | 82 | 205 | 93 | 96 |
77 | 91 | 229 | 99 | ||||
62.5 | 87# | 89 | 297 | 114 | 113 | ||
80 | 79 | 266 | 111 | ||||
125 | 89 | 78 | 257 | 96 | 92 | ||
87 | 83 | 229 | 88 | ||||
187.5 | 87 | 72 | 256 | 99 | 98 | ||
68 | 70 | 196 | 97 | ||||
250 | 68 | 81 | 226 | 112 | 115 | ||
84 | 66 | 299 | 119 | ||||
Positive Control | 3-Methylcholanthrene | 7 | 89 | 37 | 563 | 212 | 215* |
68 | 38 | 442 | 218 | ||||
Negative Control | Negative (Not Specified) | 0 | 84 | 108 | 189 | 75 | 81* |
91 | 107 | 239 | 88 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 55 | 78 | 152 | 92 | 103 |
56 | 72 | 190 | 113 | ||||
Test Chemical | Benzo(e)pyrene | 0.313 | 50 | 54 | 169 | 112 | 103 |
56 | 63 | 159 | 94 | ||||
0.625 | 64 | 62 | 203 | 106 | 104 | ||
73# | 54 | 224 | 103 | ||||
1.25 | 41 | 31 | 178 | 147 | 125 | ||
52 | 40 | 161 | 103 | ||||
2.5 | 71 | 26 | 362 | 171 | 163 | ||
59 | 30 | 273 | 155 | ||||
5 | |||||||
73 | 18 | 387 | 178 | ||||
7.5 | |||||||
Positive Control | Dimethylnitrosoamine | 100 | 6r | 4 | 44 | 238 | |
8r | 5 | 52 | 224 | ||||
Negative Control | Negative (Not Specified) | 0 | 68 | 133 | 158 | 77 | 77* |
70 | 117 | 160 | 76 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 73 | 134 | 192 | 87 | 102 |
50 | 66 | 177 | 118 | ||||
Test Chemical | Benzo(e)pyrene | 0.625 | 43 | 54 | 205 | 158 | 199* |
40 | 46 | 287 | 240 | ||||
1.25 | 53 | 33 | 399 | 251 | 241* | ||
40 | 36 | 273 | 230 | ||||
2.5 | 51 | 28 | 411 | 270 | 287* | ||
60 | 27 | 542 | 303 | ||||
5 | 78 | 12 | 632 | 271 | 364* | ||
36 | 7 | 497 | 456 | ||||
Positive Control | 3-Methylcholanthrene | 7 | |||||
Negative Control | Negative (Not Specified) | 0 | 37r | 83 | 153 | 140 | |
47r | 67 | 139 | 100 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 62 | 85 | 55 | 30 | 28 |
70 | 115 | 56 | 27 | ||||
Test Chemical | Benzo(e)pyrene | 0.313 | 49 | 71 | 38 | 26 | 28 |
41 | 73 | 38 | 31 | ||||
0.625 | 40# | 60 | 35 | 29 | 38 | ||
42 | 63 | 59 | 46 | ||||
1.25 | 40 | 50 | 61 | 50 | 44 | ||
54 | 54 | 60 | 37 | ||||
2.5 | 65 | 26 | 105 | 54 | 57* | ||
62 | 38 | 111 | 60 | ||||
5 | 78 | 7 | 228 | 97 | 85* | ||
54 | 7 | 117 | 72 | ||||
7.5 | |||||||
Positive Control | 3-Methylcholanthrene | 5 | 23 | 2 | 421 | 606 | 674* |
16 | 2 | 364 | 743 | ||||
Negative Control | Negative (Not Specified) | 0 | 38r | 80 | 26 | 23 | |
50r | 98 | 56 | 37 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 113 | 121 | 102 | 30 | |
123r | 121 | 114 | 31 | ||||
Test Chemical | Benzo(e)pyrene | 1.25 | 112 | 56 | 216 | 64 | 74* |
76 | 45 | 190 | 84 | ||||
2.5 | 93 | 40 | 306 | 109 | 103* | ||
83 | 52 | 240 | 96 | ||||
5 | 95 | 37 | 294 | 103 | 139* | ||
78 | 28 | 410 | 175 | ||||
7.5 | 92 | 51 | 462 | 167 | 163* | ||
94 | 71 | 449 | 159 | ||||
10 | 89 | 59 | 422 | 159 | 138* | ||
120 | 48 | 423 | 118 | ||||
Positive Control | 3-Methylcholanthrene | 5 | 68 | 26 | 563 | 276 | 282* |
58 | 20 | 503 | 287 | ||||
Negative Control | Negative (Not Specified) | 0 | 133r | 121 | 132 | 33 | |
116 | 79 | 112 | 32 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 79 | 83 | 151 | 64 | 48 |
103 | 115 | 160 | 52 | ||||
68 | 90 | 97 | 47 | ||||
96 | 113 | 85 | 30 | ||||
Test Chemical | Benzo(e)pyrene | 1 | 72 | 58 | 325 | 151 | 133* |
81 | 67 | 277 | 114 | ||||
85 | 57 | 340 | 134 | ||||
2 | 75 | 51 | 393 | 175 | 176* | ||
66# | 35 | 376.5 | 191 | ||||
81 | 56 | 395 | 163 | ||||
4 | 78 | 40 | 461 | 198 | 203* | ||
55 | 37 | 401 | 242 | ||||
81 | 42 | 411 | 169 | ||||
5 | 60 | 29 | 459 | 257 | 201* | ||
73 | 28 | 413 | 189 | ||||
62# | 23 | 291 | 156 | ||||
6 | 62 | 28 | 389 | 210 | 183* | ||
85 | 32 | 471 | 184 | ||||
60# | 5 | 279 | 156 | ||||
8 | 75 | 19 | 382 | 169 | 212* | ||
55 | 12 | 417 | 254 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 27 | 8 | 388 | 476 | 402* |
51 | 16 | 386 | 252 | ||||
28# | 2 | 402 | 479 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination