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Study Information
Study Attribute Value
CEBS Accession Number: 002-01703-0001-0000-4
Chemical Name: Benzofuran
CASRN: 271-89-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 622347_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/20/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 461 0.447 9.22 25.5 0.000
Test Chemical Benzofuran 
11         
 50 1044 496 0.475 9.92 25.5 6.355 
36.7       
 50 1033 574 0.556 11.48 25.5 24.391 
110         
 50 1042 581 0.558 11.62 25.5 24.821 
367         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1034 623 0.603 12.46 25.5 34.880
Mitomycin-C 
 0.01      
 5 104 186 1.788 37.20 25.5 300.367
Trend: 4.193        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/09/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 490 0.472 9.80 25.7 0.000
Test Chemical Benzofuran 
174.9       
 50 1027 681 0.663 13.62 31.0 40.468 
199         
 50 1024 691 0.675 13.82 31.0 42.948 
249.9       
 50 1022 703 0.688 14.06 31.0 45.715 
297         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1034 693 0.670 13.86 25.7 41.976
Mitomycin-C 
 0.01      
 5 103 193 1.874 38.60 25.7 296.937
Trend: 5.872        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/20/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 482 0.464 9.64 25.5 0.000
Test Chemical Benzofuran 
110         
 50 1037 530 0.511 10.60 25.5 10.171 
367         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 5 105 196 1.867 39.20 25.5 302.379
Trend: 1.540        
Probability: 0.062        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/03/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1024 464 0.453 9.28 25.5 0.000
Test Chemical Benzofuran 
174.9       
 50 1033 616 0.596 12.32 25.5 31.602 
199         
 50 1040 581 0.559 11.62 25.5 23.289 
249.9       
 50 1033 705 0.682 14.10 33.0 50.616 
297         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1032 722 0.700 14.44 25.5 54.397
Cyclophosphamide 
2         
 5 100 168 1.680 33.60 25.5 270.759
Trend: 6.368        
Probability: 0.000