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Study Information
Study Attribute Value
CEBS Accession Number: 002-01703-0008-0000-1
Chemical Name: Benzofuran
CASRN: 271-89-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 158938
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 103 99 197 64 79
    63 96 155 82
    94 104 177 63
    86 101 272 106
Test Chemical Benzofuran 
12.5       
 100 131 157 52 56
    91 137 162 59
  
25         
 83 110 243 97 80
    82 164 153 62
  
50         
 85# 138 197 77 76
    97 123 217 74
  
100         
 88 61 163 62 56
    82 86 123 50
  
200         
 125r 17 436 117
    90 14 383 142
Positive Control Methyl Methane Sulfonate 
15         
 58 52 443 257 267*
    42 34 352 277

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 92 100 152 55 58
    89 102 130 49
    84 105 158 63
    108 93 214 66
Test Chemical Benzofuran 
50         
 72 66 136 63 58
    93 68 146 52
  
100         
 68# 31 180 88 89
    65 26 175 90
  
150         
 32# 6 267 280 229*
    45 10 242 179
  
200         
   
Positive Control Methyl Methane Sulfonate 
15         
 42 24 469 371 337*
    41 26 368 303

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 109 101 92 28 31
    94 99 81 29
    93 92 86 31
    99 108 104 35
Test Chemical Benzofuran 
100         
 107 33 203 63 58*
    75 30 117 52
  
125         
 73 21 177 81 75*
    59 22 122 69
  
150         
 67 16 218 109 103*
    82 11 241 98
  
175         
 78 10 335 143 134*
    84 9 315 125
  
200         
 89 8 364 136 136*
    72 9 291 136
  
225         
   
Positive Control Methyl Methane Sulfonate 
15         
 27 16 254 314 330*
    31 19 323 345

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination