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Study Information
Study Attribute Value
CEBS Accession Number: 002-01705-0001-0000-6
Chemical Name: Benzoin
CASRN: 119-53-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 016819_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
No Activation  3   
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/09/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 357 0.340 7.14 26.0 -11.634
Dimethyl Sulfoxide 
0         
 50 1049 404 0.385 8.08 26.0 0.000
Test Chemical Benzoin 
5         
 50 1045 389 0.372 7.78 26.0 -3.344 
16         
 50 1050 440 0.419 8.80 26.0 8.807 
50         
 50 1046 381 0.364 7.62 26.0 -5.423 
160         
 50 1047 437 0.417 8.74 26.0 8.375 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1051 2302 2.190 46.04 26.0 468.718
Trend: 0.931        
Probability: 0.176        

Trial #: 2    Activation: No Activation    Date: 01/25/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 421 0.402 8.42 26.0 0.000
Negative (Not Specified) 
0         
 50 1047 439 0.419 8.78 26.0 4.375
Test Chemical Benzoin 
50         
 50 1038 403 0.388 8.06 26.0 -3.353 
100         
 50 1038 442 0.426 8.84 26.0 6.000 
200         
 0 0 0 0.000 0.00 42.0 N/A 
200         
 0 0 0 0.000 0.00 26.0 N/A 
300         
 0 0 0 0.000 0.00 42.0 N/A 
300         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1039 1932 1.859 38.64 26.0 362.882
Trend: 1.038        
Probability: 0.150        

Trial #: 3    Activation: No Activation    Date: 12/28/1983    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1034 405 0.392 8.10 26.0 3.851
Dimethyl Sulfoxide 
0         
 50 1042 393 0.377 7.86 26.0 0.000
Test Chemical Benzoin 
100         
 50 1036 483 0.466 9.66 46.5 23.613 
200         
 50 1036 462 0.446 9.24 46.5 18.238 
300         
 50 1050 533 0.508 10.66 46.5 34.590 
400         
 50 1045 541 0.518 10.82 46.5 37.264 
500         
 50 1042 502 0.482 10.04 46.5 27.735
Positive Control Mitomycin-C 
 0.005     
 50 1044 1785 1.710 35.70 26.0 353.328
Trend: 4.379        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/09/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 440 0.420 8.80 26.0 5.927
Dimethyl Sulfoxide 
0         
 50 1041 413 0.397 8.26 26.0 0.000
Test Chemical Benzoin 
160         
 50 1041 398 0.382 7.96 26.0 -3.632 
500         
 50 1043 440 0.422 8.80 26.0 6.333 
1600         
 50 1047 472 0.451 9.44 26.0 13.631 
2000         
 50 1054 437 0.415 8.74 26.0 4.506
Positive Control Cyclophosphamide 
1.5       
 50 1043 1122 1.076 22.44 26.0 171.150
Trend: 1.963        
Probability: 0.025        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 01/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1039 391 0.376 7.82 26.0 2.356
Dimethyl Sulfoxide 
0         
 50 1039 382 0.368 7.64 26.0 0.000
Test Chemical Benzoin 
200         
 50 1023 412 0.403 8.24 26.0 9.540 
500         
 50 1029 461 0.448 9.22 26.0 21.853 
1000         
 50 1039 520 0.500 10.40 26.0 36.126 
1500         
 50 1031 515 0.500 10.30 26.0 35.863 
2000         
 18 372 141 0.379 7.83 26.0 3.093
Positive Control Cyclophosphamide 
1.5       
 50 1030 1307 1.269 26.14 26.0 245.136
Trend: 4.555        
Probability: 0.000