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Study Information
Study Attribute Value
CEBS Accession Number: 002-01705-0013-0000-9
Chemical Name: Benzoin
CASRN: 119-53-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 542967
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Equivocal
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 76 93 76 33 28
    66 100 47 24
    84 94 69 28
    73 113 59 27
Test Chemical Benzoin 
15.6       
 68 69 64 31 34
    74 63 74 33
    60 70 64 36
  
31.3       
 82 78 74 30 34
    65 68 55 28
    71 47 92 43
  
62.5       
 43 35 57 44 37
    57 44 51 30
    47 37 50 36
  
125         
 76 16 125 55 46*
    69 14 89 43
    70 17 81 39
Positive Control Ethyl Methane Sulfonate 
250         
 43 30 704 552 588*
    37 30 727 655
    42 30 695 558

Nonactivation Trial: 2 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 47r 43 51 37 21
    52# 75 24 15
    74 113 59 27
    66 112 39 20
Test Chemical Benzoin 
25         
 42# 63 49 39 39*
    54 84 65 40
  
50         
 56 74 33 20 27
    60 50 25 14
    49 57 68 46
  
100         
 47 28 43 30 36*
    33 25 57 57
    50 44 29 19
  
125         
 62 23 54 29 29
    51 39 38 25
    52 27 52 33
  
150         
 57 15 53 31 26
    74 19 49 22
    78# 14 57 24
  
200         
 68 11 83 40 34*
    66 5 62 31
    58 9 51 29
Positive Control Ethyl Methane Sulfonate 
250         
 54 57 445 273 289*
    54 51 489 305

Induced S9 Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 81 114 69 28 29
    98# 100 74 25
    86 87 86 33
Test Chemical Benzoin 
1.25      
 88# 81 59 22 24
    87 117 67 26
  
2.5       
 79 101 71 30 29
    107 115 88 28
  
5         
 92# 65 120 43 41
    97 61 105 36
    89 57 116 43
  
10         
 76 36 120 53 61*
    91 28 192 70
  
15         
 65 23 163 84 83*
    73# 18 177 81
  
20         
 77 9 228 98 106*
    72# 8 276 127
    84# 15 229 91
  
30         
   
   
Positive Control 3-Methylcholanthrene 
2.5       
 76# 61 515 226 213*
    90# 58 539 201

Induced S9 Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 99# 125 80 27 27
    75# 92 47 21
    88 83 84 32
Test Chemical Benzoin 
1.25      
 78 85 70 30 25
    68# 75 46 23
    80# 94 56 23
  
2.5       
 96# 91 61 21 24
    78 89 62 27
  
5         
 64 44 102 53 53*
    72# 39 114 53
  
10         
 60# 16 200 112 101*
    45 16 138 101
    63# 17 170 89
  
15         
 60 9 203 112
   
  
20         
   
   
Positive Control 3-Methylcholanthrene 
2.5       
 77# 71 505 220 220*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination