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Study Information
Study Attribute Value
CEBS Accession Number: 002-01706-0001-0000-7
Chemical Name: Benzonitrile
CASRN: 100-47-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 562549_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/29/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 400 0.388 8.00 25.5 0.000
Test Chemical Benzonitrile 
5         
 50 1029 448 0.435 8.96 25.5 12.218 
16.7       
 50 1031 408 0.396 8.16 25.5 2.000 
50         
 50 1028 451 0.439 9.02 25.5 13.079 
166.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1030 544 0.528 10.88 25.5 36.132
Mitomycin-C 
 0.01      
 5 105 175 1.667 35.00 25.5 329.583
Trend: 1.232        
Probability: 0.109        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/29/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 433 0.421 8.66 25.5 0.000
Test Chemical Benzonitrile 
5         
 50 1021 440 0.431 8.80 25.5 2.313 
16.7       
 50 1019 397 0.390 7.94 25.5 -7.504 
50         
 50 1006 429 0.426 8.58 25.5 1.243 
166.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1025 613 0.598 12.26 25.5 41.985
Cyclophosphamide 
2         
 5 103 179 1.738 35.80 25.5 312.592
Trend: -0.316        
Probability: 0.624