Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01712-0019-0000-3
Chemical Name:	Benzyl acetate
CASRN:	140-11-4
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	311211
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	98	120	155	53	36
			86	98	89	35
			94	81	95	34
			83	102	53	21
Test Chemical	Benzyl acetate	700	118	75	187	53	59*
			109	86	213	65	59*
		900	69	50	173	84	86*
			71	50	187	88	86*
		1100	76	54	189	83	75*
			71	54	142	67	75*
		1300	73	43	223	102	102*
			65	42	198	102	102*
		1500	73	17	245	112	105*
			69	23	203	99	105*
		1700

Positive Control	Methyl Methane Sulfonate	15	44	34	298	226	204*
Positive Control			51	37	280	182	204*

Nonactivation Trial: 2 Experiment Call: Negative
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	68	102	159	78	72
			78	102	132	57
			70	98	141	67
			61	99	158	86
Test Chemical	Benzyl acetate	800	74	111	110	50	61
			68	109	148	73	61
		1000	76	74	132	58	52
			90	116	125	46	52
		1200	72	70	154	72	62
			85	74	131	51	62
		1400	71	67	131	61	60
			85	69	148	58	60
Positive Control	Methyl Methane Sulfonate	15	42	28	302	239	231*
Positive Control			37	33	251	224	231*

Nonactivation Trial: 3 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	67	100	65	32	35
			54	125	58	36
			49r	91	40	27
			55	75	58	35
Test Chemical	Benzyl acetate	600	60	100	63	35	46
			65	95	113	58	46
		800	66	89	84	43	47
			73	114	114	52	47
		1000	73	87	144	66	70*
			66	80	145	73	70*
		1200	74	62	165	75	67*
			70#	76	124.5	59	67*
		1400	72	43	128	59	64*
			85	52	174	69	64*
		1600

Positive Control	Methyl Methane Sulfonate	15	29	32	223	258	199*
Positive Control			42	37	176	140	199*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination