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Study Information
Study Attribute Value
CEBS Accession Number: 002-01712-0019-0000-3
Chemical Name: Benzyl acetate
CASRN: 140-11-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 311211
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 98 120 155 53 36
    86 98 89 35
    94 81 95 34
    83 102 53 21
Test Chemical Benzyl acetate 
700         
 118 75 187 53 59*
    109 86 213 65
  
900         
 69 50 173 84 86*
    71 50 187 88
  
1100         
 76 54 189 83 75*
    71 54 142 67
  
1300         
 73 43 223 102 102*
    65 42 198 102
  
1500         
 73 17 245 112 105*
    69 23 203 99
  
1700         
   
Positive Control Methyl Methane Sulfonate 
15         
 44 34 298 226 204*
    51 37 280 182

Nonactivation Trial: 2 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 68 102 159 78 72
    78 102 132 57
    70 98 141 67
    61 99 158 86
Test Chemical Benzyl acetate 
800         
 74 111 110 50 61
    68 109 148 73
  
1000         
 76 74 132 58 52
    90 116 125 46
  
1200         
 72 70 154 72 62
    85 74 131 51
  
1400         
 71 67 131 61 60
    85 69 148 58
Positive Control Methyl Methane Sulfonate 
15         
 42 28 302 239 231*
    37 33 251 224

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 67 100 65 32 35
    54 125 58 36
    49r 91 40 27
    55 75 58 35
Test Chemical Benzyl acetate 
600         
 60 100 63 35 46
    65 95 113 58
  
800         
 66 89 84 43 47
    73 114 114 52
  
1000         
 73 87 144 66 70*
    66 80 145 73
  
1200         
 74 62 165 75 67*
    70# 76 124.5 59
  
1400         
 72 43 128 59 64*
    85 52 174 69
  
1600         
   
Positive Control Methyl Methane Sulfonate 
15         
 29 32 223 258 199*
    42 37 176 140

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination