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Study Information
Study Attribute Value
CEBS Accession Number: 002-01712-0020-0000-5
Chemical Name: Benzyl acetate
CASRN: 140-11-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 351266
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call:
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 60 92 130 72 72
    60 108 130 72
Test Chemical Benzyl acetate 
 0.25      
 68 127 130 64 78
    62 116 173 93
  
 0.5       
 63 104 130 69 60
    62 100 96 51
  
 0.75      
 62 103 170 92 83
    57 77 128 75
  
1         
 57 49 139 82 92
    61 59 186 102
  
1.25      
   
Positive Control Hycanthone 
10         
 32 48 387 405 405*
Hycanthone 
500         
 26 37 575 752 764*
    25 43 570 776

Induced S9 Trial: 1 Experiment Call:
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 67 102 224 112 126
    60 101 271 152
    62 97 215 115
Test Chemical Benzyl acetate 
 0.25      
 62 107 316 169 185
    56 86 338 202
  
 0.5       
 58 82 468 269 244*
    58 86 383 219
  
 0.75      
 52 63 557 355 342*
    53 77 521 330
  
1         
 55 65 688 420 439*
    53 51 734 459
  
1.25      
 32 22 773 801 803*
    31 19 736 804
  
1.5       
 5r 1 287 2126
  
1.75      
   
Positive Control 3-Methylcholanthrene 
6         
 5r 1 151 1007
    5r 1 203 1450
3-Methylcholanthrene 
10         
 37 34 555 498 498*

Induced S9 Trial: 2 Experiment Call:
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 63 86 216 114 114
    79 112 222 93
    70 101 285 136
Test Chemical Benzyl acetate 
 0.25      
 67 100 229 114 106
    83 120 242 98
  
 0.5       
 66 85 460 232 186*
    68 72 287 141
  
 0.75      
 59 67 408 231 255*
    62 64 517 279
  
1         
 61 58 480 264 254*
    70 69 511 243
  
1.25      
 59 54 663 374 446*
    40 31 618 519
Positive Control 3-Methylcholanthrene 
6         
 23 8 392 564 564*
    4r 1 63 485

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination