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Study Information
Study Attribute Value
CEBS Accession Number: 002-01714-0001-0000-6
Chemical Name: Benzyl alcohol
CASRN: 100-51-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 944840_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 01/16/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 412 0.394 8.24 26.0 -9.388
Dimethyl Sulfoxide 
0         
 50 1027 446 0.434 8.92 26.0 0.000
Test Chemical Benzyl alcohol 
16         
 50 1041 448 0.430 8.96 26.0 -0.902 
50         
 50 1044 489 0.468 9.78 26.0 7.856 
160         
 50 1037 466 0.449 9.32 26.0 3.477 
500         
 50 1048 481 0.459 9.62 26.0 5.686 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1040 699 0.672 13.98 26.0 54.767
Mitomycin-C 
 0.01      
 50 1047 2367 2.261 47.34 26.0 420.580
Trend: 1.038        
Probability: 0.150        

Trial #: 2    Activation: No Activation    Date: 02/21/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 442 0.426 8.84 27.0 0.000
Negative (Not Specified) 
0         
 50 1039 451 0.434 9.02 27.0 1.938
Test Chemical Benzyl alcohol 
500         
 50 1042 490 0.470 9.80 27.0 10.434 
750         
 50 1033 507 0.491 10.14 27.0 15.261 
1000         
 50 1039 505 0.486 10.10 27.0 14.143 
1250         
 50 1034 569 0.550 11.38 27.0 29.231 
1500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1053 1343 1.275 26.86 27.0 199.518
Mitomycin-C 
 0.01      
 10 210 769 3.662 76.90 27.0 759.968
Trend: 3.775        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/16/1984    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 395 0.379 7.90 26.5 0.000
Negative (Not Specified) 
0         
 50 1045 369 0.353 7.38 26.5 -6.850
Test Chemical Benzyl alcohol 
16         
 50 1044 384 0.368 7.68 26.5 -2.971 
50         
 50 1046 456 0.436 9.12 26.5 15.002 
160         
 50 1046 436 0.417 8.72 26.5 9.958 
500         
 50 1046 446 0.426 8.92 26.5 12.480 
1600         
 50 1048 456 0.435 9.12 26.5 14.782 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1043 490 0.470 9.80 26.5 23.932
Cyclophosphamide 
2         
 50 1043 1168 1.120 23.36 26.5 195.413
Trend: 2.630        
Probability: 0.004        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/27/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 431 0.412 8.62 26.0 0.000
Negative (Not Specified) 
0         
 50 1040 460 0.442 9.20 26.0 7.242
Test Chemical Benzyl alcohol 
500         
 50 1046 445 0.425 8.90 26.0 3.150 
1600         
 50 1043 477 0.457 9.54 26.0 10.885 
3000         
 50 1040 474 0.456 9.48 26.0 10.506 
4000         
 31 647 330 0.510 10.65 26.0 23.666 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1041 636 0.611 12.72 26.0 48.131
Cyclophosphamide 
2         
 10 210 312 1.486 31.20 26.0 260.225
Trend: 2.848        
Probability: 0.002