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Study Information
Study Attribute Value
CEBS Accession Number: 002-01714-0002-0000-7
Chemical Name: Benzyl alcohol
CASRN: 100-51-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 944840_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Negative 
No Activation  3  Positive 
Induced Rat Liver S9  3_S9  Weakly Positive* 
No Activation  4  Negative 
Induced Rat Liver S9  4_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 04/17/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Benzyl alcohol 
250         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1600         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
3000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 100 67 0.670 46.0 34 0.340 27.0 32 0.320 26.0 1 0.010 1.0
Trend: 0.717 0.000 0.717  
Probability: 0.237 0.000 0.237  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/05/1984    Harvest Time: 12.3 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Benzyl alcohol 
1600         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
3000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
4000         
 100 69 0.690 52.0 5 0.050 5.0 64 0.640 50.0 0 0.000 0.0 
5000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 24 0.240 22.0 10 0.100 10.0 14 0.140 14.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 59 1.180 72.0 33 0.660 54.0 25 0.500 42.0 1 0.020 1.0
Trend: 9.521 2.759 9.310  
Probability: 0.000 0.003 0.000  


Trial #:2   Activation: No Activation    Date: 04/17/1984    Harvest Time: 17 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Benzyl alcohol 
500         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
1600         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
3000         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
4000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 100 67 0.670 46.0 34 0.340 27.0 32 0.320 26.0 1 0.010 1.0
Trend: 0.359 1.266 -0.318  
Probability: 0.360 0.103 0.625  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/16/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Benzyl alcohol 
50         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
160         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0 
1600         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
5000         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 31 0.310 25.0 18 0.180 17.0 13 0.130 11.0 0 0.000 0.0
Cyclophosphamide 
50         
 100 49 0.490 38.0 14 0.140 14.0 35 0.350 28.0 0 0.000 0.0
Trend: 0.853 0.398 0.776  
Probability: 0.197 0.345 0.219  


Trial #:3   Activation: No Activation    Date: 02/21/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Benzyl alcohol 
2000         
 100 4 0.040 4.0 1 0.010 1.0 2 0.020 2.0 1 0.010 1.0 
3000         
 100 5 0.050 4.0 1 0.010 1.0 4 0.040 3.0 0 0.000 0.0 
4000         
 100 18 0.180 12.0 2 0.020 2.0 16 0.160 12.0 0 0.000 0.0 
5000         
 20 6 0.300 20.0 0 0.000 0.0 6 0.300 20.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 39 0.390 27.0 13 0.130 10.0 26 0.260 22.0 0 0.000 0.0
Mitomycin-C 
1         
 50 45 0.900 56.0 24 0.480 36.0 21 0.420 32.0 0 0.000 0.0
Trend: 3.172 0.362 3.862  
Probability: 0.001 0.359 0.000  


Trial #:3_S9   Activation: Induced Rat Liver S9    Date: 04/17/1984    Harvest Time: 18 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Benzyl alcohol 
1600         
 100 5 0.050 4.0 0 0.000 0.0 5 0.050 4.0 0 0.000 0.0 
3000         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
4000         
 100 49 0.490 32.0 20 0.200 16.0 28 0.280 24.0 1 0.010 1.0 
5000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 29 0.290 21.0 11 0.110 9.0 18 0.180 16.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 40 0.800 46.0 30 0.600 40.0 10 0.200 16.0 0 0.000 0.0
Trend: 5.706 4.096 5.125  
Probability: 0.000 0.000 0.000  


Trial #:4   Activation: No Activation    Date: 01/26/1984    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Benzyl alcohol 
160         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
500         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
1600         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
5000         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 38 0.380 28.0 25 0.250 21.0 12 0.120 12.0 1 0.010 1.0
Mitomycin-C 
1         
 50 31 0.620 44.0 9 0.180 18.0 22 0.440 34.0 0 0.000 0.0
Trend: -0.414 -0.712 -0.475  
Probability: 0.661 0.762 0.683  


Trial #:4_S9   Activation: Induced Rat Liver S9    Date: 02/29/1984    Harvest Time: 15 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: Benzyl alcohol 
500         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
1600         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
3000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
4000         
 100 26 0.260 22.0 4 0.040 4.0 22 0.220 18.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 72 0.720 39.0 39 0.390 25.0 23 0.230 20.0 10 0.100 1.0
Trend: 4.899 1.689 4.995  
Probability: 0.000 0.046 0.000