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Study Information
Study Attribute Value
CEBS Accession Number: 002-01714-0009-0000-4
Chemical Name: Benzyl alcohol
CASRN: 100-51-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 464779
Study Result: Equivocal


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 64 110 88 46 50
    42r 92 55 44
    52 74 108 69
    70 116 76 36
Test Chemical Benzyl alcohol 
156.25      
 85 126 89 35 34
    92 95 94 34
  
312.5       
 69 98 123 59 58
    71 112 119 56
  
625         
 104 132 164 53 58
    88 86 166 63
  
1250         
 95 134 134 47 57
    73 79 146 67
  
2500         
 82 82 170 69 67
    94 78 181 65
Positive Control Methyl Methane Sulfonate 
15         
 28 27 213 254 222*
    26 24 150 191

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 83 101 74 30 38
    86 101 121 47
    78 101 79 34
    63 97 77 41
Test Chemical Benzyl alcohol 
2500         
 82 97 92 38 37
    87 95 97 37
  
3000         
 67 56 98 49 43
    81 70 91 37
  
3500         
 75 56 104 46 43
    92 73 111 40
  
4000         
 36 20 52 48 58
    63 41 128 68
  
4500         
 76 21 263 115 106*
    104 20 302 97
  
5000         
   
Positive Control Methyl Methane Sulfonate 
15         
 31 31 153 164 203*
    27 29 194 242

Nonactivation Trial: 3 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 62 90 101 54 48
    71# 99 115 54
    99 103 139 47
    102 108 111 36
Test Chemical Benzyl alcohol 
250         
 88 86 90 34 40
    60 73 83 46
  
500         
 79 89 91 39 40
    88 86 110 42
  
1500         
 67 68 75 37 33
    60 55 51 28
  
2500         
 82 39 76 31 35
    85 53 100 39
  
3500         
   
Positive Control Methyl Methane Sulfonate 
15         
 40 24 206 172 227*
    33 21 282 282

Nonactivation Trial: 4 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 73 119 66 30 35
    56 110 76 45
    62 101 69 37
    61 70 52 28
Test Chemical Benzyl alcohol 
3200         
 67 73 76 38 27
    65 65 33 17
  
3400         
 81 59 56 23 29
    81 56 85 35
  
3600         
 71 43 57 27 27
    73 65 61 28
  
3800         
 66 38 50 25 28
    81 32 73 30
Positive Control Methyl Methane Sulfonate 
15         
 31 32 137 147 135*
    26 26 97 123

Induced S9 Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 80 112 81 34 37
    66 87 91 46
    79 107 60 25
    60 95 81 45
Test Chemical Benzyl alcohol 
250         
 89 89 121 46 37
    81 112 67 28
  
500         
 94 103 131 47 51
    82 93 134 55
  
1500         
 75 96 111 49 46
    77 73 97 42
  
2500         
 55 54 55 34 43
    84 64 134 53
  
3500         
 79 13 185 78
   
  
4500         
   
Positive Control 3-Methylcholanthrene 
2.5       
 58 35 490 279 279*
    129r 83 634 164

Induced S9 Trial: 2 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 69 104 59 29 29
    65 103 47 24
    62 87 68 37
    63 106 50 27
Test Chemical Benzyl alcohol 
250         
 66 106 72 36 37
    70 107 78 37
  
500         
 51 79 61 40 33
    60 89 46 26
  
1500         
 70 83 71 34 36
    60 83 69 39
  
2500         
 75 76 60 27 23
    57 62 34 20
  
3500         
   
Positive Control 3-Methylcholanthrene 
2.5       
 57 56 262 154 164*
    63 59 327 173

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination