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Study Information
Study Attribute Value
CEBS Accession Number: 002-01715-0001-0000-7
Chemical Name: Benzyl chloride
CASRN: 100-44-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 186977_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/29/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1017 480 0.472 9.60 26.0 0.000
Test Chemical Benzyl chloride 
1.67      
 50 1010 524 0.519 10.48 26.0 9.923 
5         
 50 1020 534 0.524 10.68 26.0 10.923 
16.7       
 25 502 497 0.990 19.88 36.0 109.765 
50         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1017 662 0.651 13.24 26.0 37.917
Mitomycin-C 
 0.01      
 5 100 138 1.380 27.60 26.0 192.388
Trend: 10.302        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/25/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1020 483 0.474 9.66 26.0 0.000
Test Chemical Benzyl chloride 
9.9       
 50 1021 608 0.595 12.16 26.0 25.757 
15.1       
 50 1030 936 0.909 18.72 32.0 91.907 
20         
 50 1026 1402 1.366 28.04 32.0 188.572 
30         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1023 602 0.588 12.04 26.0 24.272
Mitomycin-C 
 0.01      
 5 102 214 2.098 42.80 26.0 343.064
Trend: 23.032        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/29/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 437 0.425 8.74 26.0 0.000
Test Chemical Benzyl chloride 
5         
 50 1007 481 0.478 9.62 26.0 12.364 
16.7       
 50 1027 579 0.564 11.58 26.0 32.623 
50         
 25 506 569 1.125 22.76 36.0 164.529 
167         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 993 668 0.673 13.36 26.0 58.248
Cyclophosphamide 
2         
 5 103 182 1.767 36.40 26.0 315.667
Trend: 14.641        
Probability: 0.000