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Study Information
Study Attribute Value
CEBS Accession Number: 002-01728-0001-0000-1
Chemical Name: Bisphenol A
CASRN: 80-05-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 791721_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/18/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 496 0.481 9.92 25.5 0.000
Test Chemical Bisphenol A 
 0.8       
 50 1020 578 0.567 11.56 25.5 17.903 
2.4       
 50 1017 528 0.519 10.56 25.5 8.022 
8         
 50 1014 596 0.588 11.92 33.5 22.294
Positive Control Mitomycin-C 
 0.001     
 50 1030 732 0.711 14.64 25.5 47.867
Mitomycin-C 
 0.01      
 5 105 241 2.295 48.20 25.5 377.558
Trend: 2.704        
Probability: 0.003        

Trial #: 2    Activation: No Activation    Date: 03/08/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 474 0.462 9.48 25.5 0.000
Test Chemical Bisphenol A 
15         
 50 1014 505 0.498 10.10 25.5 7.801 
20         
 50 1020 466 0.457 9.32 34.5 -1.109 
25         
 50 1041 519 0.499 10.38 34.5 7.916 
30         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1026 658 0.641 13.16 25.5 38.819
Mitomycin-C 
 0.01      
 5 103 182 1.767 36.40 25.5 282.475
Trend: 0.639        
Probability: 0.261        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/18/1983    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1015 449 0.442 8.98 25.5 0.000
Test Chemical Bisphenol A 
24         
 50 1015 483 0.476 9.66 25.5 7.572 
80         
 0 0 0 0.000 0.00 0.0 N/A
Trend: 1.114        
Probability: 0.133        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/16/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 437 0.425 8.74 25.5 0.000
Test Chemical Bisphenol A 
30         
 50 1019 438 0.430 8.76 25.5 1.114 
40         
 50 1036 463 0.447 9.26 25.5 5.132 
50         
 50 1016 512 0.504 10.24 25.5 18.546 
60         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1041 559 0.537 11.18 25.5 26.320
Cyclophosphamide 
2         
 5 104 240 2.308 48.00 25.5 442.862
Trend: 2.665        
Probability: 0.004