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Study Information
Study Attribute Value
CEBS Accession Number: 002-01728-0002-0000-2
Chemical Name: Bisphenol A
CASRN: 80-05-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 791721_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 03/15/1983    Harvest Time: 21 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Bisphenol A 
20         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 
30         
 100 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0 3 0.030 3.0 
40         
 100 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 2 0.020 2.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.062     
 50 28 0.560 36.0 19 0.380 28.0 7 0.140 10.0 2 0.040 4.0
Trend: 0.666 -1.306 0.000  
Probability: 0.253 0.904 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/22/1983    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 2 0.020 2.0
Test Chemical: Bisphenol A 
30         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 
40         
 100 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 2 0.020 2.0 
50         
 100 4 0.040 3.0 0 0.000 0.0 3 0.030 2.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
50         
 100 18 0.180 28.0 8 0.080 12.0 7 0.070 12.0 3 0.030 6.0
Trend: 0.437 -0.470 1.837  
Probability: 0.331 0.681 0.033  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 02/23/1983    Harvest Time: 10.7 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 6.0 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 3 0.030 3.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: Bisphenol A 
30         
 100 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0 3 0.030 3.0 
40         
 100 6 0.060 6.0 2 0.020 2.0 1 0.010 1.0 3 0.030 3.0 
50         
 100 15 0.150 14.0 3 0.030 3.0 7 0.070 6.0 5 0.050 5.0 
60         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 24 0.240 28.0 6 0.060 12.0 7 0.070 14.0 11 0.110 4.0
Trend: 3.084 0.165 3.198  
Probability: 0.001 0.434 0.001