Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01728-0014-0000-5 |
Chemical Name: | Bisphenol A |
CASRN: | 80-05-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 831513 |
Study Result: | Negative |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 68 | 96 | 68 | 34 | 32 |
87 | 111 | 79 | 30 | ||||
85 | 61 | 76 | 30 | ||||
74 | 131 | 78 | 35 | ||||
Test Chemical | Bisphenol A | 6.25 | 87 | 78 | 52 | 20 | 22 |
93 | 76 | 62 | 22 | ||||
101 | 110 | 76 | 25 | ||||
12.5 | 73 | 29 | 61 | 28 | 24 | ||
93 | 98 | 55 | 20 | ||||
83 | 99 | 58 | 23 | ||||
25 | 92 | 86 | 88 | 32 | 29 | ||
79 | 51 | 60 | 25 | ||||
65 | 22 | 60 | 31 | ||||
50 | |||||||
Positive Control | Methyl Methane Sulfonate | 5 | 32 | 6 | 355 | 374 | 444* |
27 | 6 | 382 | 472 | ||||
26 | 7 | 375 | 487 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 120 | 104 | 105 | 29 | 30 |
116 | 101 | 122 | 35 | ||||
106 | 99 | 89 | 28 | ||||
96 | 96 | 83 | 29 | ||||
Test Chemical | Bisphenol A | 5 | 113 | 97 | 113 | 33 | 35 |
110 | 90 | 111 | 34 | ||||
111 | 77 | 123 | 37 | ||||
10 | 113 | 82 | 87 | 26 | 25 | ||
103 | 93 | 80 | 26 | ||||
120 | 109 | 86 | 24 | ||||
20 | 116 | 76 | 82 | 23 | 25 | ||
104 | 75 | 74 | 24 | ||||
85 | 83 | 68 | 27 | ||||
30 | 101 | 65 | 90 | 30 | 28 | ||
116 | 63 | 90 | 26 | ||||
112 | 72 | 92 | 27 | ||||
40 | 107 | 20 | 89 | 28 | 28 | ||
102 | 39 | 78 | 25 | ||||
90 | 26 | 80 | 30 | ||||
50 | |||||||
85 | 13 | 69 | 27 | ||||
60 | |||||||
Positive Control | Methyl Methane Sulfonate | 5 | 142r | 98 | 875 | 205 | 152* |
87 | 78 | 375 | 144 | ||||
67 | 67 | 323 | 160 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 99 | 88 | 69 | 23 | 27 |
89 | 94 | 98 | 37 | ||||
95 | 111 | 82 | 29 | ||||
97 | 107 | 56 | 19 | ||||
Test Chemical | Bisphenol A | 5 | 86 | 88 | 124 | 48 | 36 |
118 | 102 | 104 | 29 | ||||
88 | 81 | 79 | 30 | ||||
10 | 110 | 102 | 120 | 36 | 40 | ||
92 | 75 | 133 | 48 | ||||
94 | 89 | 97 | 34 | ||||
20 | 88 | 56 | 97 | 37 | 38 | ||
122r | 82 | 100 | 27 | ||||
106 | 67 | 127 | 40 | ||||
30 | 118 | 65 | 120 | 34 | 38 | ||
115 | 83 | 120 | 35 | ||||
100 | 65 | 136 | 45 | ||||
40 | 113 | 69 | 103 | 30 | 32 | ||
117 | 62 | 113 | 32 | ||||
106 | 59 | 110 | 35 | ||||
50 | 89 | 33 | 105 | 39 | 48* | ||
84 | 40 | 88 | 35 | ||||
61 | 16 | 129 | 70 | ||||
60 | |||||||
Positive Control | Methyl Methane Sulfonate | 5 | 49 | 35 | 369 | 249 | 279* |
63 | 51 | 521 | 276 | ||||
67 | 51 | 624 | 311 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 97 | 102 | 107 | 37 | 38 |
90 | 110 | 81 | 30 | ||||
76 | 93 | 101 | 44 | ||||
81 | 95 | 97 | 40 | ||||
Test Chemical | Bisphenol A | 25 | 153r | 81 | 119 | 26 | 59 |
74 | 33 | 106 | 48 | ||||
75 | 38 | 158 | 70 | ||||
50 | 84 | 28 | 95 | 38 | 32 | ||
139r | 43 | 123 | 30 | ||||
76 | 35 | 58 | 26 | ||||
100 | 60 | 18 | 107 | 59 | 46 | ||
48 | 14 | 61 | 42 | ||||
82 | 24 | 91 | 37 | ||||
200 | |||||||
Positive Control | 3-Methylcholanthrene | 2.5 | 47 | 44 | 350 | 251 | 124* |
88# | 101 | 74 | 28 | ||||
29 | 28 | 81 | 92 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 79 | 117 | 166 | 70 | 74 |
68 | 100 | 168 | 83 | ||||
72 | 110 | 154 | 72 | ||||
72 | 73 | 154 | 71 | ||||
Test Chemical | Bisphenol A | 5 | 53 | 86 | 104 | 66 | 63 |
59 | 120 | 104 | 59 | ||||
61 | 119 | 119 | 66 | ||||
10 | 65 | 119 | 121 | 62 | 51 | ||
58# | 119 | 87 | 50 | ||||
82 | 150 | 96 | 39 | ||||
20 | 84 | 137 | 118 | 47 | 60 | ||
85 | 146 | 122 | 48 | ||||
59 | 70 | 149 | 84 | ||||
30 | 67 | 103 | 117 | 58 | 51 | ||
88 | 97 | 137 | 52 | ||||
97 | 146 | 126 | 43 | ||||
40 | 75 | 103 | 137 | 61 | |||
50 | 94 | 70 | 101 | 36 | 46 | ||
83# | 131 | 120 | 48 | ||||
85 | 135 | 134 | 53 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 110 | 164 | 368 | 112 | 109 |
110 | 191 | 349 | 106 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 104 | 106 | 156 | 50 | 46 |
111 | 108 | 141 | 43 | ||||
114 | 128 | 149 | 44 | ||||
105 | 58 | 156 | 49 | ||||
Test Chemical | Bisphenol A | 5 | 121r | 121 | 129 | 36 | 36 |
116 | 128 | 108 | 31 | ||||
109 | 115 | 132 | 40 | ||||
10 | 114 | 112 | 131 | 38 | 42 | ||
111 | 121 | 136 | 41 | ||||
107 | 68 | 146 | 46 | ||||
20 | 112 | 99 | 104 | 31 | 42 | ||
85 | 62 | 135 | 53 | ||||
111 | 71 | 143 | 43 | ||||
30 | 104 | 16 | 76 | 24 | 34 | ||
100 | 34 | 128 | 43 | ||||
119 | 68 | 121 | 34 | ||||
40 | 84 | 9 | 112 | 45 | 44 | ||
107 | 13 | 133 | 42 | ||||
103 | 20 | 143 | 46 | ||||
50 | |||||||
Positive Control | 3-Methylcholanthrene | 2.5 | 71 | 32 | 1065 | 499 | 476* |
48 | 12 | 769 | 534 | ||||
93 | 48 | 1103 | 396 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination