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Study Information
Study Attribute Value
CEBS Accession Number: 002-01729-0001-0000-2
Chemical Name: Bisphenol A diglycidyl ether
CASRN: 1675-54-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 935710_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/21/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 445 0.433 8.90 25.6 0.000
Test Chemical Bisphenol A diglycidyl ether 
 0.284     
 50 1030 684 0.664 13.68 25.6 53.409 
 0.853     
 50 1028 903 0.878 18.06 25.6 102.921 
2.8       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1035 682 0.659 13.64 25.6 52.222
Mitomycin-C 
 0.01      
 5 105 205 1.952 41.00 25.6 351.022
Trend: 12.450        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/10/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 513 242 0.472 9.68 25.6 0.000
Test Chemical Bisphenol A diglycidyl ether 
2.5       
 25 510 320 0.627 12.80 25.6 33.009 
5         
 25 516 522 1.012 20.88 25.6 114.448 
10         
 25 521 940 1.804 37.60 25.6 282.465 
20.5       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 25 522 367 0.703 14.68 25.6 49.038
Mitomycin-C 
 0.01      
 5 101 226 2.238 45.20 25.6 374.339
Trend: 22.477        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/21/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1022 431 0.422 8.62 25.6 0.000
Test Chemical Bisphenol A diglycidyl ether 
2.8       
 50 1026 528 0.515 10.56 25.6 22.028 
8.5       
 50 1032 525 0.509 10.50 25.6 20.629 
28.4       
 50 1045 1439 1.377 28.78 31.3 226.526 
85.3       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1022 668 0.654 13.36 25.6 54.988
Cyclophosphamide 
2         
 5 103 156 1.515 31.20 25.6 259.138
Trend: 24.810        
Probability: 0.000