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Study Information
Study Attribute Value
CEBS Accession Number: 002-01729-0002-0000-3
Chemical Name: Bisphenol A diglycidyl ether
CASRN: 1675-54-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 935710_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 04/20/1984    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Bisphenol A diglycidyl ether 
5         
 100 9 0.090 9.0 2 0.020 2.0 6 0.060 6.0 1 0.010 1.0 
10         
 100 14 0.140 12.0 2 0.020 2.0 12 0.120 11.0 0 0.000 0.0 
20         
 100 19 0.190 13.0 2 0.020 2.0 17 0.170 12.0 0 0.000 0.0 
25         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 50 3 0.060 6.0 2 0.040 4.0 1 0.020 2.0 0 0.000 0.0
Trend: 2.747 1.048 2.902  
Probability: 0.003 0.147 0.002  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/20/1984    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Bisphenol A diglycidyl ether 
29.9       
 100 11 0.110 10.0 4 0.040 4.0 7 0.070 6.0 0 0.000 0.0 
39.9       
 100 9 0.090 8.0 0 0.000 0.0 9 0.090 8.0 0 0.000 0.0 
50.3       
 100 11 0.110 9.0 0 0.000 0.0 8 0.080 8.0 3 0.030 1.0 
60.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Cyclophosphamide 
25         
 25 7 0.280 24.0 3 0.120 12.0 4 0.160 12.0 0 0.000 0.0
Trend: 1.591 -1.500 1.883  
Probability: 0.056 0.933 0.030  


Trial #:2   Activation: No Activation    Date: 05/25/1984    Harvest Time: 10.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 50 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 50 1 0.020 2.0 0 0.000 0.0 1 0.020 2.0 0 0.000 0.0
Test Chemical: Bisphenol A diglycidyl ether 
5         
 50 7 0.140 12.0 1 0.020 2.0 6 0.120 10.0 0 0.000 0.0 
10         
 50 12 0.240 18.0 2 0.040 4.0 10 0.200 16.0 0 0.000 0.0 
15.1       
 50 20 0.400 30.0 0 0.000 0.0 20 0.400 30.0 0 0.000 0.0 
20         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 9 0.180 14.0 2 0.040 4.0 7 0.140 12.0 0 0.000 0.0
Mitomycin-C 
 0.5       
 25 19 0.760 44.0 8 0.320 24.0 11 0.440 32.0 0 0.000 0.0
Trend: 3.868 0.369 3.968  
Probability: 0.000 0.356 0.000