Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01729-0002-0000-3 |
Chemical Name: | Bisphenol A diglycidyl ether |
CASRN: | 1675-54-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 935710_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
No Activation | 2 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Bisphenol A diglycidyl ether | 5 | 100 | 9 | 0.090 | 9.0 | 2 | 0.020 | 2.0 | 6 | 0.060 | 6.0 | 1 | 0.010 | 1.0 |
10 | 100 | 14 | 0.140 | 12.0 | 2 | 0.020 | 2.0 | 12 | 0.120 | 11.0 | 0 | 0.000 | 0.0 | ||
20 | 100 | 19 | 0.190 | 13.0 | 2 | 0.020 | 2.0 | 17 | 0.170 | 12.0 | 0 | 0.000 | 0.0 | ||
25 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 50 | 3 | 0.060 | 6.0 | 2 | 0.040 | 4.0 | 1 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Trend: | 2.747 | 1.048 | 2.902 | ||||||||||||
Probability: | 0.003 | 0.147 | 0.002 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 2.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Bisphenol A diglycidyl ether | 29.9 | 100 | 11 | 0.110 | 10.0 | 4 | 0.040 | 4.0 | 7 | 0.070 | 6.0 | 0 | 0.000 | 0.0 |
39.9 | 100 | 9 | 0.090 | 8.0 | 0 | 0.000 | 0.0 | 9 | 0.090 | 8.0 | 0 | 0.000 | 0.0 | ||
50.3 | 100 | 11 | 0.110 | 9.0 | 0 | 0.000 | 0.0 | 8 | 0.080 | 8.0 | 3 | 0.030 | 1.0 | ||
60.4 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 5 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 25 | 25 | 7 | 0.280 | 24.0 | 3 | 0.120 | 12.0 | 4 | 0.160 | 12.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.591 | -1.500 | 1.883 | ||||||||||||
Probability: | 0.056 | 0.933 | 0.030 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 50 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 50 | 1 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 1 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Bisphenol A diglycidyl ether | 5 | 50 | 7 | 0.140 | 12.0 | 1 | 0.020 | 2.0 | 6 | 0.120 | 10.0 | 0 | 0.000 | 0.0 |
10 | 50 | 12 | 0.240 | 18.0 | 2 | 0.040 | 4.0 | 10 | 0.200 | 16.0 | 0 | 0.000 | 0.0 | ||
15.1 | 50 | 20 | 0.400 | 30.0 | 0 | 0.000 | 0.0 | 20 | 0.400 | 30.0 | 0 | 0.000 | 0.0 | ||
20 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.15 | 50 | 9 | 0.180 | 14.0 | 2 | 0.040 | 4.0 | 7 | 0.140 | 12.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.5 | 25 | 19 | 0.760 | 44.0 | 8 | 0.320 | 24.0 | 11 | 0.440 | 32.0 | 0 | 0.000 | 0.0 | |
Trend: | 3.868 | 0.369 | 3.968 | ||||||||||||
Probability: | 0.000 | 0.356 | 0.000 |