Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01730-0002-0000-5 |
Chemical Name: | Biurea |
CASRN: | 110-21-4 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 805767_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Negative |
Induced Rat Liver S9 | 2_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Medium | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Biurea | 160 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
500 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
1600 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | ||
Positive Control: | Mitomycin-C | 0.25 | 100 | 30 | 0.300 | 25.0 | 12 | 0.120 | 11.0 | 17 | 0.170 | 16.0 | 1 | 0.010 | 1.0 |
Mitomycin-C | 1 | 50 | 42 | 0.840 | 56.0 | 22 | 0.440 | 32.0 | 19 | 0.380 | 28.0 | 1 | 0.020 | 1.0 | |
Trend: | 1.076 | -0.409 | 1.228 | ||||||||||||
Probability: | 0.141 | 0.659 | 0.110 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Medium | 0 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Biurea | 160 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
500 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
1600 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 44 | 0.440 | 34.0 | 29 | 0.290 | 26.0 | 15 | 0.150 | 14.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 50 | 50 | 44 | 0.880 | 58.0 | 19 | 0.380 | 30.0 | 24 | 0.480 | 40.0 | 1 | 0.020 | 1.0 | |
Trend: | 0.416 | -1.637 | 1.429 | ||||||||||||
Probability: | 0.339 | 0.949 | 0.076 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Medium | 0 | 100 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 1.0 | |
Test Chemical: | Biurea | 1600 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
3000 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
4000 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.25 | 100 | 12 | 0.120 | 11.0 | 9 | 0.090 | 8.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 1 | 50 | 25 | 0.500 | 40.0 | 21 | 0.420 | 36.0 | 4 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.391 | 1.195 | 0.538 | ||||||||||||
Probability: | 0.348 | 0.116 | 0.295 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 |
Medium | 0 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Biurea | 1600 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
3000 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
4000 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 6 | 0.060 | 6.0 | 2 | 0.020 | 2.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 32 | 0.320 | 24.0 | 15 | 0.150 | 12.0 | 17 | 0.170 | 15.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 50 | 50 | 26 | 0.520 | 38.0 | 17 | 0.340 | 26.0 | 9 | 0.180 | 18.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.152 | 0.858 | -0.345 | ||||||||||||
Probability: | 0.440 | 0.195 | 0.635 |